Project Grant R01HG014687
- The federal Project Grant award of $993,446 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is supporting the Sloan-Kettering Institute for Cancer Research in New York to develop statistical and machine learning approaches that bridge the gaps between human genetics and single-cell omics data. The goal is to decode the regulatory activity underlying disease variants, accurately link variants to genes in relevant cell types, and identify disease-critical...
- The National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) awarded a $3,371,645 Project Grant to Boston Medical Center Corporation (BMC) to develop a comprehensive suite of computational tools to unlock the potential of spatial subcellular transcriptomics data. Specifically, the project will: Create a scalable and extensible database infrastructure to enable interactive analysis of large spatial transcriptomics datasets on standard computing systems. Develop novel methods...
- This $2,963,428 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) aims to develop critical infrastructure and tools for interpreting genomic data. The project will create high-quality genome assembly workflows, comprehensive documentation, and interactive training materials to make these advanced genomic analysis capabilities accessible to a wide audience of biology researchers. This will enable downstream discoveries in areas such as...
- This $276,308 federal Project Grant award from the National Science Foundation's Integrative Activities program (CFDA 47.083) aims to advance computational and statistical methods for studying single-cell genomics data in the context of tissue organization. The overarching goals are to: (a) develop novel spatial algorithms to identify gene expression patterns and tissue changes in 2D space, (b) gain new data-driven insights on tissue dynamics in development and disease, and (c) create an...
- This $1,350,896 federal Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a multimodal massively parallel reporter assay (MPRA) platform to study the mechanisms underlying gene regulatory sequence function. The overarching goals are to develop tools capable of elucidating the interactions between chromatin, regulatory factors, and transcriptional processes that regulate gene expression. Key objectives include...
- The Trustees of Columbia University in the City of New York received a $435,475 Project Grant from the National Human Genome Research Institute (NHGRI) under the "Human Genome Research" (CFDA 93.172) program. The grant funds the development of novel machine learning methods for analyzing spatial transcriptomic data without the need for paired single-cell data. The proposed computational toolbox will enable the characterization of diverse cell states and their spatial dynamics through...
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), provides $757,157 to the University of California, San Diego (UC San Diego) to develop complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants. The key objectives are to: 1) Develop a method called SCBE-SEQ that combines genome editing with single-cell sequencing to...
- This federal Project Grant award of $130,680 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of computational technologies for single-cell functional genomics. The project aims to address the challenge of systematically characterizing the functional roles of genetic variants associated with common diseases, by developing robust computational frameworks to decode the epigenetic response of cells to intercellular communications....
- The National Human Genome Research Institute (NHGRI), under CFDA 93.172 - Human Genome Research, awarded a $550,810 Project Grant to the University of California, Irvine to develop an AI-assisted laser capture microdissection (AI-LCM) approach for high-throughput, genome-wide spatial transcriptomics analysis. The project aims to optimize in-situ DNA nanoball generation and sequencing, enhance AI-assisted LCM to efficiently isolate single cells, and refine sequencing protocols to link genomic...
- The National Human Genome Research Institute (NHGRI) awarded the University of Wisconsin System a $407,645 Project Grant under the "Human Genome Research" (CFDA 93.172) program to develop statistical methods for constructing gene co-expression networks from population-scale single-cell RNA sequencing (scRNA-seq) data. The two-year project aims to: 1) develop a de-biasing approach to estimate gene-gene correlations from scRNA-seq data, accounting for technical limitations like low...
This $2,409,233 Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop a suite of advanced statistical tools with user-friendly interfaces to enhance the reliability and power of single-cell and spatial omics data analysis through experimental-data-based in silico data generation. The key products and services to be delivered under this grant include: This project aims to extend the capabilities of computational genomic research and foster more accurate and reproducible data-driven discoveries in the field of single-cell and spatial omics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.4m | 9/19/25 |