Project Grant R01HD122901
- The National Institute of Child Health and Human Development awarded the University of Missouri System $500,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate molecular mechanisms underlying endometriosis-associated infertility. The award is a Project Grant (R56HD122660). The research addresses the role of the transcription factor FOXA2 in endometriosis development and related infertility. The investigative team will...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College $351,945 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate inflammation resolution mechanisms in endometrial health and disease. The research dissects how specialized pro-resolving mediators, a class of lipid-derived molecules that orchestrate inflammation resolution, operate in the human endometrium across the menstrual cycle. The...
- The National Institute of Child Health and Human Development (NICHD) of the Department of Health and Human Services awarded North Carolina State University $673,394 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode epigenetic networks that orchestrate endometrial function. The project addresses molecular mechanisms underlying uterine dysfunction in recurrent implantation failure and recurrent pregnancy loss, which remain major...
- The National Institute of Child Health and Human Development awarded The Trustees of Columbia University in the City of New York $444,824 on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to engineer human pluripotent stem cell (HPSC)-derived endometrial organoids for modeling regeneration and disease mechanisms. The project will develop an innovative platform that recapitulates physiological interactions and developmental trajectories...
- The National Institute of Child Health and Human Development awarded Marshall University Research Corporation $147,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate epigenetic regulation of CXCR4 in endometriosis. The research examines aberrant promoter methylation dynamics of CXCR4, a master regulator involved in endometrial cell migration, stem cell trafficking, and lesion formation in endometriosis. The project aims...
- The National Institute of Child Health and Human Development awarded Oregon State University $444,498 on August 18, 2026, to develop nanoparticle-mediated chemodynamic therapy for endometriosis under the Child Health and Human Development Extramural Research program (CFDA 93.865, Project Grant R01HD121601). Endometriosis affects approximately 176 million women worldwide, causing severe pelvic pain and infertility with no cure. Current clinical therapies cause infertility, and surgical lesion...
- Federal Project Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $426,250 Project Grant award dated August 6, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research through July 31, 2027, investigating the role of Protein Arginine Methyltransferase 1 (PRMT1) in regulating trophoblast development and...
- The National Institute of Child Health and Human Development, a component of the Department of Health and Human Services, awarded Northwestern University $684,253 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transcriptional and epigenome dysregulation in uterine leiomyomas. The research integrates advanced molecular and genomic technologies, bioinformatics, and a patient-derived precision-cut ex vivo tissue explant...
- The National Institute of Child Health and Human Development awarded The Washington University $427,625 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate retinoic acid signaling and uterine epithelial cell fate determination. The research examines how retinoic acid signaling maintains uterine epithelial cell identity during adult homeostasis and tests hypotheses about the antagonistic relationship between retinoic acid and...
- The National Institute of Child Health and Human Development awarded Michigan State University $3.548 million on September 12, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct transcriptomic analyses of early endometriotic lesion development. The recipient, doing business as Henry Ford Health+Michigan State University Health Sciences, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal endometriotic lesions...
The National Institute of Child Health and Human Development awarded the University of Kansas Medical Center Research Institute, Inc. $662,769 on September 1, 2026, to define the role of RPLP1 and RGS1 in endometriosis and adenomyosis pathophysiology under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project investigates cellular mechanisms underlying two common gynecological diseases in women of reproductive age. The recipient will characterize RPLP1 and RGS1 expression in adenomyosis and endometriosis tissues, examine their involvement in epithelial-mesenchymal transition and macrophage differentiation through in vitro studies, and demonstrate functional roles using experimental mouse models of both diseases. The work is performed at the recipient's Kansas City, Kansas facility. The period of performance runs through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $662.8k | 8/24/26 |