Project Grant R01HD122913
- The National Institute of Child Health and Human Development awarded Worcester Polytechnic Institute $555,371 on June 1, 2026, to develop bioengineered in vitro models of uterine fibroids under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funded work creates two novel in vitro platforms—one with tunable transport properties and one modeling intramural uterine fibroids surrounded by myometrium—to study how altered signaling from sex hormones (estrogen...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $500,000 on September 1, 2026, under the Child Health and Human Development Extramural Research grant program (CFDA 93.865) to conduct single-cell molecular characterization and computational drug discovery for fertility-sparing treatment of uterine fibroids. The project applies single-nucleus RNA sequencing and computational drug-repurposing methods to identify...
- The National Institute of Child Health and Human Development awarded The University of Texas Health Science Center at San Antonio $699,359 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode the pseudouridine epitranscriptome in uterine fibroids and develop therapeutic interventions targeting pseudouridine synthase enzymes. The research addresses the molecular mechanisms underlying uterine fibroid development by investigating...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development (NICHD) of the Department of Health and Human Services awarded North Carolina State University $673,394 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode epigenetic networks that orchestrate endometrial function. The project addresses molecular mechanisms underlying uterine dysfunction in recurrent implantation failure and recurrent pregnancy loss, which remain major...
- The National Institute of Child Health and Human Development awarded The Trustees of Columbia University in the City of New York $444,824 on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to engineer human pluripotent stem cell (HPSC)-derived endometrial organoids for modeling regeneration and disease mechanisms. The project will develop an innovative platform that recapitulates physiological interactions and developmental trajectories...
- The National Institute of Child Health and Human Development (NICHD), a component of the Department of Health and Human Services National Institutes of Health, awarded $148,994 to the University of Wisconsin System (operating through its University of Wisconsin - Madison Division) on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, assistance type Project Grant F31HD119998). The recipient will conduct research investigating the role of the...
- The National Institute of Child Health and Human Development awarded Northwestern University $240,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to develop ovarian somatic organoids as a drug discovery model for reproductive longevity. The research addresses ovarian aging, characterized by loss of egg quantity and quality leading to infertility and altered endocrine function. The funded work builds on the recipient's...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College $351,945 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate inflammation resolution mechanisms in endometrial health and disease. The research dissects how specialized pro-resolving mediators, a class of lipid-derived molecules that orchestrate inflammation resolution, operate in the human endometrium across the menstrual cycle. The...
- The National Institute of Child Health and Human Development awarded The Washington University $427,625 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate retinoic acid signaling and uterine epithelial cell fate determination. The research examines how retinoic acid signaling maintains uterine epithelial cell identity during adult homeostasis and tests hypotheses about the antagonistic relationship between retinoic acid and...
The National Institute of Child Health and Human Development, a component of the Department of Health and Human Services, awarded Northwestern University $684,253 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transcriptional and epigenome dysregulation in uterine leiomyomas. The research integrates advanced molecular and genomic technologies, bioinformatics, and a patient-derived precision-cut ex vivo tissue explant culture system to explore how histone H3 lysine 27 acetylation and EP300/CBP coactivators drive disease manifestation in uterine fibroids. The work employs cell-based and tissue-based assay platforms to identify the epigenome as a key driver of uterine tumorigenesis and fibrosis, with the goal of advancing therapeutic approaches for a condition affecting up to 70 percent of women and causing significant morbidity through bleeding, pelvic pain, infertility, and uterine dysfunction. Work is performed in Illinois. The period of performance extends from September 1, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type for NIH R01 awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $684.3k | 8/31/26 |