Project Grant R01HD121946
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $456,500 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, effective June 1, 2026, through May 31, 2028, supports research to molecularly characterize the human cervical epithelium during pregnancy and establish novel in vitro models of cervical tissue. The...
- Federal Project Grant Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $657,377 Project Grant effective September 1, 2025, through May 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award funds research to advance understanding of human trophoblast development and function using pluripotent stem cell models. The research addresses critical gaps in knowledge regarding...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $167,353 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded on July 17, 2025, with a completion date of June 30, 2030. This research project, titled "Syphilis in Pregnancy: Placental Histopathology and Transcriptomic Linkage to Outcomes," will investigate...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded $429,000 in Project Grant funding to the University of Colorado-Denver for research conducted under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was obligated on August 6, 2025, with a project completion date of July 31, 2027. This R21 mechanism grant supports research utilizing induced pluripotent stem cell (iPSC)...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $620,820 Project Grant awarded August 1, 2025, by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). This five-year award, concluding July 31, 2030, supports a single-arm Phase III clinical trial evaluating the efficacy of cryopreserved human umbilical cord (HUC) grafts as meningeal patches in...
- Federal Grant Award Summary The University of Connecticut Health Center received a $249,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The award funds research focused on mapping inter-cellular trophoblast-decidual signaling and its effects on placental invasion at the maternal-fetal interface. The...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $467,542 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 15, 2025, with completion targeted for July 31, 2027. The award supports development of a fully automated, open-source computational pipeline utilizing deep learning algorithms and regional radiomics...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $324,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective April 1, 2026, through August 31, 2031. This award funds investigator-initiated biomedical research examining the role of gut microbiota-derived butyrate in modulating inflammation and...
- Federal Project Grant Award Summary Yale University received a $1.28M project grant awarded August 1, 2025, by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research examining the role of decidual extracellular vesicles (EVs) in mediating placental insufficiency, a condition affecting 3-8% of pregnancies worldwide and contributing to fetal growth restriction and...
- Federal Project Grant Award Summary The University of Pennsylvania received a $164,190 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded February 1, 2026, with completion targeted for June 30, 2027. This research initiative investigates the role and regulation of the IC2 imprinted gene cluster in extravillous trophoblast (EVT) differentiation, with particular...
Federal Project Grant Summary The University of Texas Health Science Center at Houston received a $688,009 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective May 15, 2026, through February 28, 2031. This award supports investigator-initiated research to advance understanding of placental biology and mechanisms underlying premature placental aging and associated pregnancy complications, including stillbirth, preeclampsia, fetal growth restriction, and preterm birth. The research deliverables focus on defining molecular and metabolic pathways governing trophoblast stem cell (TSC) differentiation and placental aging. Specifically, the project examines how stress-induced TSC differentiation and exhaustion contribute to premature placental senescence, with particular emphasis on the regulatory roles of the transcription factor C/EBPβ and microRNA clusters (mir-371373 and their murine orthologs mir-290295) in maintaining TSC identity and self-renewal capacity. The research outputs are expected to generate foundational knowledge applicable to developing therapeutic strategies to preserve placental regenerative capacity and improve pregnancy outcomes in at-risk populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $688.0k | 5/19/26 |