Project Grant R01HD119206
- The National Institute of Child Health and Human Development awarded Cornell University $139,206 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of centromere genetic variation in non-random aneuploidy and early pregnancy loss. The research will identify genetic variants associated with chromosomal abnormalities in early pregnancy loss cases, with focus on how centromere variation—specifically genetic and...
- The National Institute of General Medical Sciences (NIGMS) awarded Cornell University $425,552 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing Project Grant R35GM165881) to conduct research on the molecular mechanisms of epigenetic centromere inheritance. The research will elucidate how the histone H3 variant CENP-A—which defines centromere identity—is stably inherited across animal generations through a mechanism that remains...
- The National Institute of General Medical Sciences awarded Cornell University $424,158 on July 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of the Kumgang/MI-2 chromatin remodeling complex and its role in transcriptional fidelity. The research will characterize how tissue-specific zinc finger proteins (ZFPs) interact with the chromatin remodeler MI-2 to repress inappropriate gene transcription. The project will...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $157,427 on May 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal MCM4 protein in zygotic DNA replication and the oocyte-to-embryo transition. The research uses live imaging, immunofluorescence, and RNA sequencing to examine how maternal MCM4 governs zygotic replication and mitotic fidelity in oocyte-specific...
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of Child Health and Human Development awarded Oklahoma Medical Research Foundation $468,875 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate homologous chromosome dynamics in mouse oocytes. The research addresses aneuploidy, which occurs in 10 to 30 percent of human gametes and typically results from chromosome segregation errors during meiosis, leading to pregnancy loss or genetic disorders such as...
- The National Institute of Child Health and Human Development awarded the University of Rochester $149,190 on February 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the molecular mechanisms of sperm dysfunction induced by meiotic drive. The project combines gene editing, genetic, and cytological approaches to study segregation distorter (SD), a sperm-killing male meiotic driver found in natural populations of Drosophila...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- Federal Grant Award Summary Magee-Womens Research Institute and Foundation received a $919,914 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 9, 2025 through September 8, 2027. The research project investigates conserved and unique features regulating meiotic crossover formation—the exchange of DNA between homologous chromosomes during meiosis. The research...
- The National Institute of Child Health and Human Development awarded $390,504 to the Regents of the University of Michigan on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support systems-level research on human primordial germ cell differentiation. The award funds research to understand the signaling and gene regulatory networks that control the differentiation of human primordial germ cell-like cells (HPGCLCs) from human pluripotent...
The National Institute of Child Health and Human Development awarded Cornell University $667,092 on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on MUTS GAMMA as a driver of crossover pathway choice in prophase I of mammalian meiosis. The research investigates how DNA double-strand breaks formed during meiosis are repaired as either crossovers or non-crossovers, focusing on the role of the MUTS GAMMA heterodimer (MSH4 and MSH5) in selecting which breaks become crossovers and ensuring their appropriate distribution across the genome. The project explores MUTS GAMMA interactors that influence decisions between Class I and Class II crossover pathways and examines mammalian-specific features of the complex. Key findings under investigation include the role of MUTS GAMMA in facilitating resolvase activity through interactions with exonuclease I and direct interactions with other pathway components. Work is performed at Ithaca, New York. The award period runs through March 31, 2031. This is a project grant, an assistance type providing support for a discrete, specified research objective.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.1k | 8/10/26 |