Project Grant R01HD117823
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College (doing business as Tufts University School of Medicine) $453,750 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate epigenetic inheritance of trauma effects through sperm microRNA changes. The research examines how trauma exposure in men correlates with altered microRNA profiles in sperm—specifically elevated levels of miRNAs 532, 361,...
- The National Institute of Child Health and Human Development awarded University of Massachusetts Boston $577,974 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate RNA binding proteins in the maintenance of male fertility and spermatogenesis. The research uses zebrafish as a model organism to elucidate how RNA regulation by ADAD1 proteins controls spermatogonial stem cell maintenance and differentiation during continuous...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts Medical School $103,686 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research probing the mammalian PIRISC cleavage mechanism. The funded research investigates how gametocyte-specific factor (GTSF) proteins accelerate the cleavage activity of PIWI-interacting RNA-induced silencing complexes (PIRISC), which silence...
- The National Institute of Child Health and Human Development awarded $149,190 to The Trustees of The University of Pennsylvania on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to determine the postfertilization regulatory functions of a sperm microRNA cluster. The research investigates how sperm microRNAs influence early embryonic development and mediate the paternal transmission of non-genetically inherited phenotypes. The project...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $478,453 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize approximately 150 early lethal mouse phenotypes occurring between fertilization and organogenesis as part of large-scale analysis of International Mouse Phenotyping Consortium (IMPC) early lethal phenotypes. The recipient will phenotype knockout alleles to...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $157,427 on May 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal MCM4 protein in zygotic DNA replication and the oocyte-to-embryo transition. The research uses live imaging, immunofluorescence, and RNA sequencing to examine how maternal MCM4 governs zygotic replication and mitotic fidelity in oocyte-specific...
- The National Institute of Child Health and Human Development awarded Yale University $456,999 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of acetyl-methyllysine in spermatogenic development. The research characterizes the distribution and regulation of acetyl-methyllysine (KACME), a histone modification combining lysine acetylation and methylation, during sperm development. Aim 1 applies custom anti-KACME...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded Harvard Medical School (operating through the Office of Research Administration of President and Fellows of Harvard College) $464,750 on August 24, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865). The award funds research on genetic variation in genes controlling sperm-egg interactions in reproductively isolated populations of the fish species Astyanax mexicanus. The research...
- The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $704,336 on August 17, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of T cells in transgenerational epigenetic inheritance. The funded research examines how the immune system, specifically T cells, can epigenetically alter phenotypes across multiple generations of progeny. Preliminary data demonstrates that T...
The National Institute of Child Health and Human Development awarded the University of Massachusetts Medical School $716,119 on July 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate dietary signaling mechanisms in male reproductive tissues and their epigenetic effects on offspring. The project explores how paternal dietary exposures influence cell composition and gene regulation in the testis, epididymis, and seminal vesicle, and identifies the cellular origins of seminal fluid signaling proteins and small molecules. The work employs epigenomics assays to characterize dietary effects on the sperm epigenome, with the goal of revealing new principles of biological inheritance and enabling prediction or manipulation of offspring phenotypes to promote health. Period of performance runs from July 25, 2026, through April 30, 2031. Work is performed in Worcester, Massachusetts. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $716.1k | 7/23/26 |