Project Grant R01HD117565
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- The Project Grant award of $692,917.00 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the federal Child Health and Human Development Extramural Research Program (CFDA 93.865). The funding supports research conducted by Children's Mercy Hospital in Missouri to investigate the impact of state safety net policies on pediatric hospitalizations and child maltreatment rates. The research aims to create a publicly available dataset of...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
- This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanism of pluripotency transitions during peri-implantation development. The $760,617 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to address the technical challenges in working with limited...
- This federal Project Grant award was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $763,886 award, granted on March 12, 2025, supports a comprehensive research project at The Children's Hospital of Philadelphia (CHOP) to identify and functionally study RNA isoforms regulated by the ESRP1/2 proteins during epithelial-mesenchymal transition (EMT)....
- The Project Grant award titled "UNDERSTANDING FUNCTIONS OF LTR RETROTRANSPOSON ACTIVATION IN PREIMPLANTATION DEVELOPMENT" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award supports research to understand how long terminal repeat (LTR) retrotransposons regulate zygotic gene activation and early embryogenesis. The research...
- The National Institute of Child Health and Human Development (NICHD), through the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), awarded a $584,317 project grant to The General Hospital Corporation (doing business as Massachusetts General Hospital) to validate and optimize their non-invasive fetal sequencing (NIFS) technology. This technology aims to enable unbiased fetal exome screening at high coverage from a maternal blood draw, which could...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $133,401 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Fred Hutchinson Cancer Center, located in Seattle, WA. The grant, awarded on September 1, 2025, is intended to develop computational models that can identify the sequence of changes a cell undergoes during differentiation and maturation, and compare changes in gene expression...
- This federal Project Grant award of $2,207,672.00, awarded on August 1, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports genetic research on large palindrome arrays in mammalian genomes. The research aims to comprehensively characterize seven large palindrome arrays in mice, testing the hypotheses that these arrays evolve to favor their own inheritance and are necessary...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This $681,829 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comprehensive research initiative focused on characterizing the human "imprintome" - the set of genes and genomic regions that exhibit parent-of-origin specific regulation. The award to Children's Mercy Hospital in Kansas City, Missouri aims to leverage the hospital's extensive resource of long-read, parentally resolved human genomes to identify hundreds of previously unknown imprinted genes and regulatory regions. Through single-cell epigenomic analyses and long-read RNA sequencing, the researchers will link these novel imprinted regions to developmental processes and disease mechanisms, with the goal of enhancing understanding and diagnosis of rare imprinting disorders. This 5-year project, running from August 2025 to April 2030, represents a significant advancement in the genomic characterization of parent-of-origin effects and their role in human health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $681.8k | 8/14/25 |