Project Grant R01HD117422
- This federal Project Grant award, valued at $180,174 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to develop a framework for designing the next generation of pediatric ARDS (Acute Respiratory Distress Syndrome) clinical trials. The key products and services to be delivered under this 5-year grant include: Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric ARDS ventilator management....
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,479,335 to the Massachusetts Institute of Technology (MIT) to conduct research related to Acute Respiratory Distress Syndrome (ARDS). The key objectives are to use "target trial emulation" from observational data to inform prospective ARDS research and clinical decision-making, develop advanced machine learning methods for...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded a $790,989 Project Grant to the Children's Research Institute to study the palliative care needs of children with rare diseases and their families. The 5-year grant, awarded on Feb 1, 2025, will fund the development and evaluation of the Family Centered (FACE) Pediatric Advance Care Planning intervention,...
- This federal Project Grant award of $224,083 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865, the Child Health and Human Development Extramural Research program, supports research on the use of oscillometry for evaluating pulmonary function in children following acute respiratory failure. The project aims to advance understanding of the long-term impacts of acute respiratory conditions, such as pneumonia and asthma, on...
- This $688,163 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by the University of Pittsburgh to study the role of indole metabolites as danger signals in the development of acute respiratory distress syndrome (ARDS). The 4-year project aims to investigate how metabolites derived from microbes can activate regulated cell death pathways and inflammatory responses in lung epithelial cells,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $153,099 to the Massachusetts Institute of Technology (MIT) to conduct research aimed at improving care for patients with Acute Respiratory Distress Syndrome (ARDS). The key objective is to leverage observational data and advanced statistical methods, known as "target trial emulation" and "g-methods", to evaluate the effects of different...
- This Project Grant award for $2,295,984.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to advance precision medicine for Acute Respiratory Distress Syndrome (ARDS) and sepsis. The project aims to address key unanswered questions about the functional immune response and biological pathways underlying two identified molecular phenotypes of these conditions, the "hyperinflammatory" and "hypoinflammatory"...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $590,565 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Vanderbilt University Medical Center (VUMC) on September 1, 2025. The grant aims to leverage bioengineering and vascular physiology technologies to develop a human ductus arteriosus (DA) construct that mimics the response of native vessels to various stimuli. This is intended to...
- This federal Project Grant award, issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $866,579 to The Children's Hospital of Philadelphia Research Institute to conduct an adaptive, parallel-stepped-wedge hybrid cluster-randomized trial. The trial aims to determine if an "Optimizing Ventilation (OPTI-VENT) Bundle" can improve cardiac arrest...
- The federal Project Grant award of $160,052 was granted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Children's Hospital of Philadelphia (CHOP) for the project "HOSPITAL FINANCIAL HEALTH, NICU STRAIN, AND NEONATAL OUTCOME VARIATION AND SUBPOPULATION DISPARITIES". The project aims to inform policies and interventions to reduce structural drivers...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $767,069 to support research on Pediatric Acute Respiratory Distress Syndrome (PARMA) management. The primary awardee is The Children's Hospital of Philadelphia Research Institute, which will investigate optimal ventilation strategies for children with ARDS, a condition affecting 45,000 U.S. children annually with a 20% mortality rate. This research aims to improve upon current ventilation protocols extrapolated from adult ARDS guidelines, which may not fully address the distinct epidemiologic and outcome profile of pediatric ARDS. The award period runs from Aug 18, 2025 to Apr 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $767.1k | 8/15/25 |