This Project Grant award, totaling $658,633, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo proteins for sperm flagella assembly and in remodeling chromatin during the final...
The National Institute of Child Health and Human Development (NICHD) awarded a $2,228,898 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Brigham & Women's Hospital Inc. in Boston, MA. The grant will fund the development of a microwell device and deep learning framework to enable efficient identification and retrieval of rare sperm from samples of men with azoospermia (absence of sperm in semen). This technology aims to provide a more...
This Project Grant award of $1,683,996 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of a novel 3D Dynamic Contrast Optical Coherence Microscopy (3D DYC-OCM) technology. The key products and services to be delivered include: Developing a novel swept source architecture and scalable parallel imaging platform to enable 3D...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop computational microscopy technologies that can overcome the challenge of tissue scattering to enable large-scale 3D imaging of tissue morphogenesis. The $337,326 award to the University of Texas at Austin will fund research to: (1) develop computational scattering models for reconstructing 3D...
This federal Project Grant award of $329,834 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research at William Marsh Rice University to visualize and understand how extracellular morphogens, specifically the Nodal signaling pathway, shape embryonic development and cell fate patterning. The research will leverage CRISPR-edited human pluripotent stem cells to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research - supports research to identify biomarkers of the sperm striated columns, a key component of the sperm centrosome. The $152,834 award to the University of Toledo will be used to examine the composition of the striated columns in bovine spermatozoa and zygotes, with the long-term goal of understanding the contribution...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,991,974 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Leland Stanford Junior University (Stanford University) effective August 1, 2024 through April 30, 2029. The grant will support the development of a novel "live embryo imaging" method for aneuploidy detection, a biopsy-free approach to preimplantation genetic testing for aneuploidy (PGT-A) that can...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $435,875.00 to the University of Texas at Austin to develop robust and accessible methods for non-invasive quantification of the mechanical properties of cell-cell junctions and the cytoplasm in vertebrate embryos. The goal is to improve the depth and breadth of understanding of embryo biomechanics...
This federal Project Grant award of $243,750 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on the maternal regulation of microtubules in egg developmental competency. The research, conducted by the Trustees of the University of Pennsylvania, investigates the dynamics, etiology, and nature of spindle-like microtubule structures and vesicle-like structures observed...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,963,122 to the University of Missouri System to conduct research on the molecular mechanisms regulating uterine development. The research aims to define critical physiological and genetic pathways that regulate uterine development, function, and regeneration in order to diagnose, treat, and prevent...