This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $674,095 to develop a novel in vivo imaging technology to directly observe and better understand the process of mammalian fertilization within the mouse fallopian tube. The 5-year project, starting December 1, 2024, aims to integrate expertise in live functional optical imaging and reproductive...
The National Institutes of Health (NIH) Office of the Director awarded a $2,624,970 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University (Stanford University) to construct the first-ever foundational in silico model of whole-embryo mouse embryogenesis. The key products to be delivered include: Establishing a large-scale 3D multi-omics cell atlas of mouse embryogenesis from embryonic day 6.5 to 16.5, involving 50 million single cells...
This $737,732 federal Project Grant award was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of Columbia University in the City of New York, with a period of performance from July 2024 to March 2029. The project aims to study the causes and consequences of DNA replication stress in the mammalian preimplantation embryo. The research will focus on identifying the...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $125,000.00 in funding to the Whitehead Institute for Biomedical Research to develop novel technologies for integrated mapping of cell state and lineage during normal development. The goal is to create comprehensive cellular and molecular atlases to understand how tissues are assembled and...
This $2,442,535 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865) will fund research to understand the long-term impact and value of implementing newborn genomic sequencing. The key objectives are to: Conduct interviews with clinicians, health system leaders, and newborn screening program coordinators to understand their needs and concerns regarding integrating newborn genomic sequencing with traditional screening programs. Follow up with...
This federal Project Grant award of $401,927, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to understand the functions of long terminal repeat (LTR) retrotransposon activation in preimplantation development. The grant recipient, Cincinnati Children's Hospital Medical Center, will utilize advanced genetic manipulation techniques such as CRISPR interference and base...
This $537,730 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop advanced in vivo magnetic resonance imaging (MRI) technologies for studying infant brain development. The primary objectives are to achieve motion-robust, high-resolution (600mm isotropic) whole-brain quantitative MRI (qMRI) and diffusion MRI (dMRI) within clinically feasible scan...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $760,617 to Boston Children's Hospital to conduct research on the mechanisms underlying pluripotency transitions during peri-implantation development. The research aims to identify key transcription factors and understand how DNA methylation regulates the transition from naive to formative...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will provide $226,608.00 over 3 years to the University of California, Santa Barbara (UCSB) to develop high-throughput, optogenetic tools for studying primate embryonic development and gastrulation. The key products and services to be delivered include: 1) Utilizing UCSB's proprietary "OptoChimp"...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is focused on developing epigenomic liquid biopsy methods for early detection and prediction of preterm birth, preeclampsia, and intrauterine growth restriction. The total grant award of $717,871 to the Magee-Womens Research Institute and Foundation aims to create non-invasive screening tools to...