This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $534,899 to Baylor College of Medicine to conduct research on the role of vitamin B12-dependent metabolic pathways in neural crest development. The project aims to use novel mouse models to identify which specific cobalamin-dependent pathways, when disrupted, lead to neural crest developmental defects, as well as investigate whether modulating the maternal environment can improve the phenotypic presentation of the resulting congenital disorder known as combined methylmalonic acidemia and homocystinuria, cblC-type (CBLC). The findings from this 5-year research project, which runs from June 1, 2025 to February 28, 2030, are expected to shed light on the pathophysiology of CBLC and potentially inform future patient treatment approaches.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $534.9k | 5/29/25 |