This Project Grant award, totaling $658,633, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo proteins for sperm flagella assembly and in remodeling chromatin during the final...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $245,619 to the University of Utah to investigate the relationship between genome mutagenesis, fertility, and health in fertile and infertile men. The key objectives are to: 1) Examine germline mutation rates from the bulk sperm of normozoospermic (fertile) men, 2) Determine if infertile,...
The Department of Agriculture's National Institute of Food and Agriculture awarded a $120,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to Virginia Polytechnic Institute & State University from July 2021 through June 2023. The grant funds research to investigate embryonic losses occurring during blastocyst hatching and embryo elongation in cattle, which can significantly impact the cattle industry. The principal investigator will...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to identify biomarkers for the sperm striated columns, a critical component of the sperm centrosome. The goal is to enable future research on the role of the striated columns in sperm motility and their contribution to the zygote centrosome during fertilization....
This $650,000 Project Grant was awarded by the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program on July 1, 2024. The grant aims to characterize placental cell types in the maternal endometrium during early stages of development in cattle, using cutting-edge techniques. The long-term goals are to understand how the placenta develops, how it interacts with the uterus, and what cells and molecules are involved in the process. A...
This $650,000 Project Grant from the National Institute of Food and Agriculture, part of the U.S. Department of Agriculture, will fund research under the Agriculture and Food Research Initiative competitive grants program. The awardee, the Agricultural Research Service located in Fort Collins, Colorado, will develop techniques using strategically-coated magnetic nano-particles to remove defective spermatozoa from bull semen. Field studies will then evaluate the reproductive potential of the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to define the mechanisms of temperature-sensitive meiotic chromosome structures in male infertility. The $248,999 award to Colorado State University, with a performance period from April 1, 2025 to March 31, 2028, will investigate how sexual dimorphisms in the synaptonemal complex (SC)...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This $550,000 Project Grant from the US Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program will fund research at Iowa State University to improve understanding and assessment of boar sperm fertility. The university will identify biochemical differences between more and less fertile boar sperm to better understand the molecular mechanisms of fertility and infertility. Researchers will also translate sperm...
The National Institute of Child Health and Human Development (NICHD) awarded a $2,228,898 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, to develop and evaluate a microwell device and deep learning framework for the accurate detection and retrieval of rare sperm in samples from men with azoospermia (lack of sperm in semen). The project aims to address the...
This $986,581 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the contribution of the paternal histone epigenome to embryo development and pregnancy loss.
The project, led by Texas A&M AgriLife Research, will utilize sperm samples from bulls with known fertility levels to establish the baseline paternal histone epigenome, determine if it is altered in low-fertility bulls, and investigate changes to preimplantation embryos generated from low-fertility bulls. This research aims to provide important insights into the mechanisms governing early embryonic development, the effects of an abnormal paternal epigenome on chromatin dynamics and embryonic genome activation, and the reasons why paternal chromatin can result in infertility and altered embryogenesis in cattle and humans. The findings have the potential to impact reproductive efficiency and clinical management of patients with infertility, poor embryogenesis, and pregnancy loss.