Project Grant R01HD115566
- This Project Grant award of $739,487.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to refine the understanding of immune heterogeneity in pediatric sepsis-induced multiple organ dysfunction syndrome (SIMODS). The key objectives are to: (1) define specific functional immune endotypes and refine the heterogeneity over time in immunosuppressive or...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $179,475 to The Children's Hospital of Philadelphia (CHOP) to conduct research on pediatric sepsis. The key objectives of the project are to define and validate a molecular subphenotyping model that can predict the severity of sepsis in children, and to test the reversibility of immune dysregulation through targeting...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $181,438 to The Children's Hospital of Philadelphia (CHOP) to conduct a prospective longitudinal study on neurocognitive outcomes and recovery trajectory for 180 school-aged pediatric sepsis survivors over 12 months. The key objectives are to evaluate the prevalence of...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This Project Grant award of $186,221 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to develop personalized therapies for pediatric sepsis. The primary objectives are to augment sepsis phenotypes through the integration of high-frequency physiologic data with electronic health record data, and to retrospectively identify sepsis subtypes that may respond differently to various...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $721,728 to the Regents of the University of Michigan to conduct research on "Modulation of Pediatric Sepsis by Virus Persistence." The research aims to identify novel biomarkers that can help define sepsis phenotypes and predict patient responses to immunomodulatory therapies. Specifically, the study will investigate how persistent...
- This $294,244 Project Grant award, funded by the Department of Health and Human Services (DHHS) Agency for Healthcare Research and Quality (AHRQ) under the Research on Healthcare Costs, Quality and Outcomes (CFDA 93.226) program, supports research to identify sepsis phenotypes associated with antibiotic-resistant pathogens. The project aims to leverage machine learning techniques, including large language models applied to clinical notes, to augment electronic health record (EHR) data and define...
- This Project Grant award of $750,561 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund the SMART-SEPSIS study. The study aims to use electronic health record data and artificial intelligence/machine learning to model individual patient response to sepsis treatment and promote early but reasoned application of the hour-1 sepsis treatment bundle for patients with suspected community-onset lung sepsis. The goal is...
- This federal Project Grant award, valued at $158,933, was provided by the National Center for Advancing Translational Sciences (NCATS), which falls under the Department of Health and Human Services. The grant, titled "Timing and Risk Factors for Developing Chronic Respiratory Failure After Pediatric Sepsis" (CFDA #93.350), will be used by the Regents of the University of Michigan to conduct research to characterize the patterns of onset and risk factors for the development of new...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is providing $174,960 to the Regents of the University of Michigan to develop and evaluate a personalized approach to initial fluid resuscitation for patients with hospital-onset sepsis. The key products and services to be delivered under this award include: 1) an electronic health record-based cohort study to understand the impact of initial fluid volume on outcomes in...
This $697,256 project grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to identify distinct subphenotypes and endotypes in children with sepsis-induced multi-organ dysfunction syndrome (MODS). The study, titled "Discovering Subphenotypes and Endotypes in Pediatric Sepsis-Induced MODS: The DISPENSE Study", will leverage data from two clinical trials (PRECISE GRACE2 and TRIPS) to perform latent class analysis and genome-wide expression profiling. The key objectives are to: 1) Identify subphenotypes in children with sepsis-induced MODS and examine how clinical outcomes and treatment response vary between these subphenotypes, and 2) Discover transcriptomic signatures that define novel subphenotypes and endotypes. The 4-year project is being conducted by the Regents of the University of Michigan, with the goal of advancing the understanding of pediatric sepsis heterogeneity and informing the development of more targeted treatment approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/31/25 | ||
| Not listed | $697.3k | 7/25/25 |