This Project Grant award of $1,564,570 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) will fund research to identify drivers of genital inflammation and HIV acquisition in women living in sub-Saharan Africa. The prime awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will collaborate with sub-awardees Universite Catholique De Louvain, The Washington University, and the University of...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $315,000 to fund research by the Regents of the University of California at Riverside. The goal is to characterize the vaginal virome and its contributions to bacterial vaginosis (BV) and associated outcomes, including HIV acquisition risk, through a longitudinal metagenomic analysis....
This federal Project Grant award of $533,750 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Florida supports research to determine the effects of bacterial vaginosis on macrophage activation and its impact on HIV risk. The key products or services to be delivered under this 5-year award include: 1) Establishing an ex-vivo macrophage stimulation model to assess changes in macrophage...
The National Institute of Child Health and Human Development (NICHD) awarded a $701,720 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant will support a 5-year research project to elucidate the effects of vaginal polyamines on immune responses, oxidative balance, and cervical remodeling in the context of...
This Project Grant award of $717,285, funded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a large-scale investigation of the vaginal ecosystem in preeclampsia. The project aims to conduct longitudinal metagenomic and metabolomic profiling of approximately 4,200 vaginal samples from 389 nulliparous pregnancies with severe preeclampsia and 389 matched controls. This research seeks to...
This $883,497 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance research on mucosal immunity and host defense against vaginal candidiasis. The award, with a period of performance from June 2024 to April 2026, will support investigations into the role of the Th17 pathway and various cytokines in promoting immunity against this common fungal infection, which affects...
This federal Project Grant award of $685,637 from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research aims to enhance research on inflammation and cognitive health among adolescents and young adults (AYA) living with perinatally acquired HIV (PHIV) and adversity in Uganda. The award supports a comprehensive study to investigate the relationship between immune dysfunction, inflammation, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $196,452 to the University of Rochester to investigate the influence of the cervicovaginal phageome on women's health and disease, especially in the context of HIV. The key objectives of this 4-year project are to: (1) characterize the cervicovaginal phageome communities over time, (2) assess the impact of AIDS...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $743,287 to Oregon Health & Science University (OHSU) to conduct a multi-disciplinary research study on endocervical mucus secretion. The goal is to uncover the cellular and pathway mechanisms that regulate mucus properties in response to hormonal changes, with the long-term aim of...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $146,550 to the University of Illinois to conduct research on the social and behavioral drivers of HIV risk among adolescent girls and young women in South Africa. The study will use a mixed-methods approach to examine the roles of mental health distress, intimate partner violence, and...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a randomized controlled trial to investigate the impact of vaginal washing cessation on cervical inflammation and HIV susceptibility among women in sub-Saharan Africa. The $1,442,972 grant, awarded on September 16, 2024, will fund a study to evaluate changes in cervicovaginal cytokine levels, activated immune cell populations, epithelial barrier integrity, and vaginal microbiome composition between participants randomized to the vaginal washing cessation intervention versus control groups. The results are expected to provide mechanistic evidence on the relationship between vaginal washing and HIV acquisition risk, which could inform public health programs to reduce vaginal washing and lower HIV susceptibility among high-risk populations. The study will be conducted by the University of Washington, a major research institution with extensive expertise in federal grant-funded scientific research across health and biomedical domains.