Project Grant R01AI184095

Award Date 8/2/24
Completion Date 6/30/29
Dollars Obligated $1.6M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,564,570 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on identifying drivers of genital inflammation and HIV acquisition in women living in sub-Saharan Africa. The project will run from August 2024 through June 2029.

The grant supports several key products and services, including:

  • Preprocessing and transformation of demographic, clinical, and behavioral data, as well as metabolomics, immune markers, and flow cytometry data
  • Applying multiblock sparse partial least squares to recover disease signatures and develop predictive models for HIV status
  • Generating and preprocessing 16S rRNA, fungal ITS, and host single-cell RNA sequencing data
  • Identifying predictive interactions from the multi-omics data and evaluating causal molecular and cellular interactions

The project involves sub-awards to Universite Catholique De Louvain and the University of Wisconsin-Madison to support specific data processing, modeling, and analytical tasks.

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