This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to comparatively assess the therapeutic potential of combined anabolic therapy versus the current standard-of-care single-drug approach in postmenopausal women at high risk of fragility fracture. The $1,175,680 award, with a performance period from September 2024 to August 2027, will be used by...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, aims to evaluate the effect of exogenous anti-Müllerian hormone (AMH) on ovarian function and fertility in non-human primates. The $724,714 award will support research to test hypotheses that AMH can induce contraception without disrupting estradiol homeostasis, reduce ovarian aging, and potentially...
This Project Grant award of $1,113,007 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, supports research to investigate the effects of gender-affirming hormone therapy (GAHT) on skeletal maturation in transgender individuals and how these effects may be mediated by modifications to the gut microbiome. The key objectives of this project are to: 1) determine the...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, CFDA 93.865 Child Health and Human Development Extramural Research) will support a $1,414,556 study on the long-term effects of selective serotonin reuptake inhibitors (SSRIs) on height growth suppression in adolescents. The 5-year study, starting on September 1, 2024, will investigate whether SSRI-induced height growth suppression plateaus or continues over a 2-year...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the mechanisms by which mechanical and hormonal signals interact within bone cells to stimulate bone formation. The $175,948 award, effective June 1, 2025 through May 31, 2030, will be conducted by The General Hospital Corporation, doing business as Massachusetts...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support a $1,600,806 observational, longitudinal study to evaluate the effects of gender-affirming hormone therapy (GAHT) on brain development and executive function in 80 transgender and gender-nonbinary (TNB) adolescents. The study will use neuroimaging techniques to assess changes...
The National Institute of Child Health and Human Development (NICHD) awarded a $478,630 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Trustees of Boston University, doing business as Boston University Medical Campus. The grant will fund a study investigating the association between childhood sexual abuse (CSA) and the risk of developing gynecologic conditions such as uterine leiomyomata, endometriosis, and polycystic ovarian syndrome. The...
The Project Grant award R43HD115425 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is supporting Theranova LLC, a veteran-owned medical device R&D company, to conduct a pilot clinical study evaluating the SOLESTIM neuromodulation system as a home-use treatment for dysmenorrhea (primary menstrual cramps). The $343,510 award will fund a 16-week,...
The National Institute on Aging (NIA), under its Aging Research Federal Grant Program (CFDA 93.866), awarded a $2,061,097 project grant to The General Hospital Corporation (Massachusetts General Hospital) for the "TESAMORELIN AS AN ADJUNCT TO EXERCISE FOR IMPROVING PHYSICAL FUNCTION IN HIV (TRIUMPH)" study. This 5-year project will assess whether the drug tesamorelin, when used in combination with a home-based exercise intervention, can improve physical function and mitigate frailty in...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at King's College London to investigate how follicle-stimulating hormone (FSH) glycoforms modulate the function of the FSH receptor (FSHR) in the aging ovary. The $739,702 award, effective August 19, 2024 through May 31, 2029, aims to elucidate the distinct roles...