Project Grant R01HD115881

Award Date 8/6/24
Completion Date 3/3/25
Dollars Obligated $1.1M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
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This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support a $1,600,806 observational, longitudinal study to evaluate the effects of gender-affirming hormone therapy (GAHT) on brain development and executive function in 80 transgender and gender-nonbinary (TNB) adolescents. The study will use neuroimaging techniques to assess changes...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,287,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Colorado-Denver. The grant will fund a 2-year feasibility study to assess the processes and outcomes related to gender-affirming care for transgender and gender diverse youth in the United States. The study aims to (1) establish the acceptability of study instruments and data...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, aims to evaluate the effect of exogenous anti-Müllerian hormone (AMH) on ovarian function and fertility in non-human primates. The $724,714 award will support research to test hypotheses that AMH can induce contraception without disrupting estradiol homeostasis, reduce ovarian aging, and potentially...
This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,559,542 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Medical College of Wisconsin, Inc. to study the cardiometabolic impacts of gender-affirming hormone therapy (GAHT) in transmasculine young adults. The project aims to determine the effects of GAHT on vascular endothelial function, cardiometabolic biomarkers, and sex hormone receptor expression in this population, compared to cisgender...
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This $158,085 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a mixed methods study to assess and promote vaginal health for transgender men on testosterone. The study aims to: 1) Develop a survey instrument to measure the vaginal health of transgender men on testosterone for clinical use; 2) Examine the psychometric properties of the survey items to finalize the...
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This Project Grant award of $1,113,007 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, supports research to investigate the effects of gender-affirming hormone therapy (GAHT) on skeletal maturation in transgender individuals and how these effects may be mediated by modifications to the gut microbiome.

The key objectives of this project are to: 1) determine the extent to which microbiome depletion or fecal material transfers alter the skeletal effects of gonadotropin-releasing hormone agonist (GnRH) treatment with and without subsequent cross-sex hormone therapy in young male and female mice; and 2) assess the contribution of microbiome-dependent expansion and migration of gut T regulatory cells, as well as changes in gut permeability, to the skeletal effects of GnRH and cross-sex hormone therapy. The project aims to elucidate the role of the gut microbiome in mediating the skeletal impacts of gender-affirming hormone treatments.

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