This federal Project Grant award, provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to understand how a novel causative gene, neuron-derived neurotrophic factor (NDNF), modulates bone morphogenetic protein (BMP) signaling in Kallmann syndrome. The $161,500 award to George Washington University, spanning September 2023 to August 2025, will fund molecular characterization of NDNF and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $407,592 to the Whitehead Institute for Biomedical Research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The research aims to: (A) discover mechanisms that repress the somatic program to allow the primordial germ cell (PGC) program to...
This Project Grant award, valued at $107,458, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the mechanisms of double strand break repair in fetal male germ cells, which are precursors to spermatogonial stem cells that supply sperm throughout a male's reproductive lifespan. The research, to be conducted at Duke...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at King's College London to investigate how follicle-stimulating hormone (FSH) glycoforms modulate the function of the FSH receptor (FSHR) in the aging ovary. The $739,702 award, effective August 19, 2024 through May 31, 2029, aims to elucidate the distinct roles...
This $146,922 Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate how misalignment of light and food cues can disrupt the function of kisspeptin neurons and prevent the normal timing of the luteinizing hormone surge. The research aims to map the monosynaptic projections of kisspeptin neurons in the anteroventral...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $980,400 to Kent State University to investigate the role of kisspeptin/neurokinin B/dynorphin (KNDY) neurons in an animal model of polycystic ovary syndrome (PCOS). The research aims to define how changes in the regulation of KNDY cells by steroid hormones and afferent...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $125,814 to The Regents of the University of California, San Francisco (UCSF) to quantify germ cell lineage dynamics during mammalian oogenesis. The goal is to characterize germ cell selection and determine the functional importance of early germ cell heterogeneity for shaping...
The Research Foundation For The State University Of New York, doing business as Stony Brook University, received a $428,536 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award is for a project titled "Novel Functions for NMDARs in Neural Crest Development" that will study the role of N-methyl-D-aspartate receptors (NMDARs) in the development of the...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $375,822 to investigate the mechanisms by which the mutation-length CGG short tandem repeat (STR) in the FMR1 gene coordinates megabase-scale heterochromatin domains and their inter-chromosomal contacts in Fragile X syndrome. The research aims to demonstrate how the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $486,750.00 to the Sloan-Kettering Institute for Cancer Research, a non-profit organization, to conduct research on the molecular and cellular pathways that drive competency for human vagal neural crest specification. The research aims to fully characterize the population of cells that exhibits...