The Johns Hopkins University received a $198,720 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) effective January 1, 2025 through December 31, 2029. The grant supports research to understand the impact of invasive mechanical ventilation on functional fibrinolysis and thromboinflammation, with the goal of developing risk prediction models to inform risk-stratified thromboprophylaxis trials in critically ill children. The project has three core aims: 1) Determine the impact of mechanical ventilation intensity on functional fibrinolysis, 2) Identify plasma biomarkers of venous thromboembolism risk, and 3) Derive an enhanced risk prediction model incorporating fibrinolytic/coagulative function, ventilation parameters, thromboinflammatory cytokines, and clinical risk factors. This work will help address the lack of trial data and pediatric-specific risk models to guide thromboprophylaxis in critically ill children, a high-risk population. The award will also support the grantee's career development through training in areas such as thrombosis pathophysiology, biomarker discovery, and clinical trial design.
Generated 2/25/25, 5:10 AM