Preventing maternal mortality from obstructed labor

Active Project Grant Awarded Last action

Award ID
R01HD100635
Recipient
Awarding agency
Obligated
$7,094,231

Award facts

Completion date 93% complete
Originally
Funding
  • $6,012,084.00 Federal
  • $1,082,147.00 Non-federal
Place of performance
Atlanta, GA 30313, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Obstructed labor accounts for 3-8% of all maternal deaths worldwide and, in many countries, is almost as prevalent today as IT was 30 years ago. Cephalopelvic disproportion (CPD) is an inadequate size of the maternal pelvis, compared to the fetal head, which prevents the fetus from passing through the pelvic cavity during delivery, causing obstructed labor. CPD-related obstructed labor requires delivery via caesarean section (c/s). CPD is especially prevalent in places like ethiopia, where girls are small in stature, grow up malnourished, marry at a young age, or become pregnant before the pelvis is fully grown. Maternal and perinatal mortality in ethiopia are among the highest in the world 7 and, 11% of maternal deaths are due to obstructed labor. The consequence of CPD-related obstructive labor (in the absence of c/s) is often maternal and/or perinatal mortality or morbidity; e.g., 1 in 250 women report having an obstetric fistula. Ethiopia has showing tremendous increases in the uptake of antenatal care and deliveries in health facilities over the past few years; yet, the rate of c/s remains very low (1.9%) due to the lack of infrastructure and surgical expertise and lack of timely assessment of the most at-risk mothers. In the ethiopian public health sector, maternal care and delivery is provided at no cost, including making provisions for high-risk pregnancies to be transferred, lodged, and cared for to appropriate facilities. There is a pressing need to develop, and translate to clinical use, safe, affordable, easy-to-use, acceptable, and accurate methods to identify mothers at high-risk of obstructed labor, before the onset of labor, so high-risk mothers can be transferred to facilities where c/s is a viable option. The purpose of this proposal is to (i) validate risk scores over an adequately powered sample, over a broader range of gestational ages (12-42 weeks) and over 6 tribal regions in ethiopia, (II) to test the feasibility of introducing a low-cost, smartphone enabled ultrasound to improve CPD risk assessment in ethiopia, (III) quantify the context of use for the proposed intervention and improve ease-of-use and beneficiary acceptability of these CPD risk assessment tools, and (IV) identify and overcome barriers to CPD risk assessment and referral follow-up of high-risk mothers to primary hospitals, where c/s is an option. Successful realization of these aims will provide adequate validation, usability, acceptability, and first clinical use data for these novel CPD risk assessment tools in ethiopia and position this innovation well for a broader clinical study to assess impact of integrating these tools across the primary health care sector in ethiopia and, ultimately, integration into routine antenatal care. Further, with modest validation studies in other countries with a high CPD burden (e.g., nigeria, india), this innovation can be translated to have a broader impact in saving lives at birth.

Transactions

Action Federal Non-federal Date
Amendment $0 $0
Amendment $482,816 $0
Amendment $43,693 $0
Amendment $43,693 $0
Amendment $436,942 $0
Amendment $436,942 $0
Amendment $436,942 $0
Amendment $485,491 $0
Amendment $485,491 $0
Amendment $485,491 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $510,289 $0
Amendment $510,289 $510,289
Amendment $510,289 $0
Amendment $571,858 $0
Original award $571,858 $571,858
Show all 18

Subawards

Subrecipient Amount Awarded
Center For Innovative Drug Development And Therapeutic Trials For Africa CDT Africa, Inc. and Georgia Tech have agreed to the following arrangements. CDT Africa, Inc. will lead the clinical data collection activities for this project… $53,676
University Of Washington Dr. Beth Kolko, Professor and Associate Chair of Human Centered Design & Engineering (HCDE) at the University of Washington, will serve as a Co-Investigator… $108,320
Ethiopian Society Of Obstetricians And Gynecologists Obstructed labor accounts for 3-8% of all maternal deaths worldwide and, in many countries, is almost as prevalent today as it was 30 years ago1-3.… $772,861

Quick answers

Who received award R01HD100635?

R01HD100635 was awarded to Georgia TECH Research Corp by National Institute of Child Health and Human Development (National Institutes of Health) on April 15, 2021.

How much is award R01HD100635 worth?

$7,094,231 has been obligated on R01HD100635: $6,012,084 in federal funding and $1,082,147 in non-federal funding.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login