Project Grant R01GM166176
- The National Institute of General Medical Sciences awarded the University of Houston System $431,750 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated nanophotonic imaging and spectroscopy technology for scalable, purification-free single exosome analysis. The research addresses limitations in current exosome analysis methods by developing a nanophotonic chip that combines three complementary nanoplasmonic techniques—localized...
- The National Institute of General Medical Sciences awarded William Marsh Rice University $410,184 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM161793) to develop streamlined synthetic methods for the synthesis of N-unprotected chiral heterocycles and amines via organo- and transition metal catalysis over a five-year performance period through January 31, 2031. The research addresses limitations in current carbon-nitrogen...
- The National Institute of General Medical Sciences awarded the University of Houston System $431,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate how dynamic oligomeric transitions of copper transporter 1 (CTR1) couple copper homeostasis with neuronal developmental pathways. The research will employ single-molecule assays including single-molecule localization microscopy and in-cell oligomer stoichiometry assays to visualize and...
- The National Institute of General Medical Sciences awarded the University of Texas Health Science Center at Houston $423,576 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning-driven computational tools for interpreting electron cryo-microscopy and electron cryo-tomography data of complex biological assemblies. The project addresses significant gaps in current cryo-EM modeling software by building a unified framework to model...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $435,412 to the University of Houston System under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project commencing September 1, 2025. Principal Investigator Dr. Yu Liu will develop TO-Triplex-Seq, a novel whole-genome sequencing technology designed to identify and map RNA-DNA triple helix structures genome-wide. The technology leverages the differential affinity of...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $406,432 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply mass spectrometry-based chemoproteomic technologies that identify functional and redox-sensitive cysteine residues in proteins, with the goal of discovering therapeutically relevant cysteines to support covalent drug development. The research program focuses on three main...
- The National Institute of General Medical Sciences awarded Texas A&M University System Health Science Center $420,657 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type Project Grant) to support research on nanoscale structure and dynamics within nuclear pores and condensates. The funded research examines intrinsically disordered proteins and regions in the proteome, with focus on transport properties of the nuclear pore complex and...
- The National Institute of General Medical Sciences awarded the University of Texas Health Science Center at Houston $429,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure and function of a metabolic network coordinating membrane phospholipid homeostasis in microorganisms. The research combines quantitative biochemical and biophysical assays—including bacterial two-hybrid analysis, biolayer interferometry, crosslinking...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $433,780 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative chemical reactions for drug discovery. The funded research pursues two research directions. First, the recipient will develop stereoselective catalytic reactions to synthesize chiral N-heterocycles—sp3-rich scaffolds prevalent in FDA-approved drugs—using...
The National Institute of General Medical Sciences awarded the University of Houston System $1.399 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a technological platform for covalent protein biologics that combine rapid tissue penetration with extended target engagement. The research will generate an accelerated platform to produce covalent and covalent-reversible biologic drugs, addressing a fundamental limitation in protein therapeutics: large proteins penetrate tissue poorly while small proteins are rapidly cleared by the kidneys. The project will accelerate sulfur(VI) fluoride exchange (SUFEX)-based covalent ligation chemistry to match the short half-life of small proteins; develop covalent-reversible biologics to reduce off-target toxicity; and evaluate cellular and in vivo activity of covalent biologics using mouse models of rheumatoid arthritis. The research will support development of small, fast-penetrating protein drugs equipped with reactive groups that form irreversible or reversible covalent bonds with their targets, then clear quickly to minimize off-target exposure. The award funds research performed in Houston, Texas through August 31, 2030. The University of Houston System is the recipient institution and serves as the prime grantee. The total obligation is $1.399 million.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 8/3/26 |