Project Grant DP2HD121549
- The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The grant supports the development of "Epigenetic Editor Therapeutics" - a novel approach to modulating gene expression without altering the DNA sequence. The project aims to create recombinant, self-delivering epigenetic editor proteins that can be taken up by cells and targeted to...
- This Project Grant awarded by the U.S. Department of Health and Human Services National Institutes of Health Office of the Director, under the NIH Research Infrastructure Programs (CFDA 93.351), provides $240,039.00 to the Baylor College of Medicine to develop a novel mouse model for detecting genome editing using CRISPR/Cas9 technology. The project aims to create an improved animal model that can more accurately track and quantify on-target and off-target genome editing events, in order to...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) Office of the Director awarded a $539,250 Project Grant under the NIH Research Infrastructure Programs (CFDA 93.351) to Baylor College of Medicine. The grant, awarded from April 1, 2025 to March 31, 2027, supports the development of mouse models with an inducible CRISPR/Cas9 system for targeted manipulation of DNA methylation. The goal is to create simple, robust tools for locus-specific editing of DNA...
- This $445,000 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on leveraging long-read transcriptomics to elucidate transcriptome complexity and advance genomic medicine. The central objective is to harness the power of long-read RNA sequencing to provide unprecedented insights into alternative splicing and its impact on gene products, which is...
- The National Institute of General Medical Sciences (NIGMS) awarded Epicypher, Inc. a $1,264,176 project grant under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a novel toolbox for studying how asymmetric post-translational modifications (PTMs) on nucleosomes regulate chromatin biology. The key products and services to be delivered include: A novel manufacturing method to efficiently generate asymmetric designer nucleosomes (A-dNucs) at...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- This Project Grant award of $429,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the biogenesis and function of cyclic phosphate-containing small non-coding RNAs (CP-RNAs). The award, effective February 8, 2025 through December 31, 2029, will enable a genome-wide expression analysis of short CP-RNAs across various cells and tissues. Key objectives include: 1) determining that...
- This Project Grant award of $306,094 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a novel epigenetic editing platform by Active Motif, Inc., a biotechnology company based in Carlsbad, California. The platform uses a new targeting approach to recruit epigenetic effectors to specific genomic loci, enabling targeted alterations to the epigenetic landscape without permanently changing DNA sequences. This innovative technology has...
The National Institutes of Health (NIH) awarded a $1,440,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Baylor College of Medicine to develop two new classes of small, cell-permeable genome regulators. The key objectives are to: (1) create bifunctional polyamides capable of editing a tandem repeat of interest in cell and animal models, (2) develop polyamides to recognize 15-20 base pair motifs occurring only once in the human genome, and (3) democratize these molecules to provide new tools to researchers and advance the field of precision genomic medicine. The grant period runs from Sep 1, 2025 to Aug 31, 2028. If successful, this research could lead to novel therapeutic strategies for repeat expansion disorders and genetic diseases more broadly.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/3/25 |