Project Grant R01GM164595
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $779,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop CRISPR-CHROMEXM, a next-generation imaging platform for direct visualization of single-molecule gene regulation during vertebrate embryogenesis. The project will integrate catalytically inactive Cas9 with the existing ChromExM (chromatin expansion microscopy) method to...
- The National Institute of General Medical Sciences awarded The Regents of the University of California (UC Riverside) $420,520 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR-Cas9 genome editing using molecular simulations and AI-driven approaches. The research integrates physics-based molecular simulations with artificial intelligence methods to advance understanding of CRISPR-Cas9 conformational dynamics,...
- The National Institute of General Medical Sciences awarded $124,767 to The Regents of the University of California, San Francisco on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance de novo protein design for catalysis and fluorescence imaging. The research tests the hypothesis that protein dynamics, particularly enrichment of productive conformations, contribute to enhanced catalytic rates in engineered proteins. Prior work under this funding...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $445,049 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA. The recipient will design novel lipid nanoparticle formulations to achieve precise, scalable delivery of biomolecules to specific cell types, combining bio-inspired...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $680,597 on April 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to conduct genome-wide in vivo CRISPR screens in human T cells identifying G protein-coupled receptor pathway targets to enhance CAR-T therapies for solid tumors. The work develops and applies a novel screening platform enabling large-scale genetic screens in human CD4+ and CD8+ T cells within tumor xenografts. Prior...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $2.255 million under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds development, application, and dissemination of integrative structure modeling methods for computing structural and spatiotemporal models of biomolecular complexes. The recipient will expand the scope of the open-source Integrative Modeling Platform...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $551,000 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop function-selective modulators of multifunctional hub proteins. The research expands two programs: developing molecular glues to stabilize native protein-protein interactions and establishing technologies to study dynamic protein-interaction networks. The work...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $433,125 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop imaging-based molecular recording methods that reconstruct the signaling history of individual cells during development. The funded research extends a signal-recording approach that uses regulated CRISPR base editors to generate mutations in engineered genomic target sites at rates...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $562,484 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation visualization and analysis software for multiscale molecular modeling. The recipient will create cutting-edge software tools that integrate visualizations and analyses of molecular structures and related biological information, including...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $123,147 on May 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate jumbo bacteriophage infection mechanisms and their potential as therapeutics against antibiotic-resistant bacteria. The research, conducted under the K99/R00 pathway, examines how FKZ-like jumbophages with genomes exceeding 200 kilobases evade bacterial immune...
The National Institute of General Medical Sciences awarded $2.164 million to The Regents of the University of California, San Francisco on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a fluorescent protein optical barcode CRISPR platform for genome-wide image-based phenotypic screening. The project will create novel CRISPR libraries using fluorescent proteins as barcodes to identify genetic perturbations in live cells and develop a recombination-free approach for manufacturing lentivirus to deliver these constructs. The recipient will establish a precise fluorescent barcode system for identifying CRISPR perturbations at the single-cell level and build a modular, genome-wide library of high-quality CRISPR perturbation constructs. The platform will be benchmarked against an established live cell reporter assay to validate robustness, reliability, and scalability. Work is performed in San Francisco, California, with a period of performance through August 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 8/18/26 |