Project Grant R01GM164521
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Lawrence Berkeley National Laboratory $526,344 under the Biomedical Research and Research Training program (CFDA 93.859) on July 21, 2025, for a project completion date of February 16, 2028. This Project Grant supports the development of advanced X-ray absorption spectroscopy (XAS) methodologies utilizing femtosecond pulses from X-ray free electron lasers (XFELs) to enable real-time, room-temperature...
- Federal Grant Award Summary Nanoprobes Inc. received a $613,744 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through February 28, 2027. The award supports the development of combined fluorescent and gold labeling reagents designed to enable correlative light and electron microscopy (CLEM) applications. These dual-function reagents integrate fluorescent tags with...
- Federal Project Grant Summary Fluorofinder, LLC received a $356,190 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 4, 2025, through September 3, 2026. The award supports development of a software-based microscopy workflow tool designed to streamline assay development and improve experimental reproducibility in the research community. The solution addresses key...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Irvine a $1.89 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The research initiative focuses on developing molecular lanterns—ultra-small ribonucleic acid (RNA) tags that assemble split luciferases—to enable real-time visualization and tracking of multiple RNA transcripts...
- Federal Project Grant Award Summary The University of California, San Francisco received a $501,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 5, 2025, with completion targeted for May 31, 2030. The grant funds fundamental research focused on bridging the gap between predicted and actual protein structures in structural biology, with particular emphasis on understanding...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $441,375 under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year project (April 1, 2026 – March 31, 2031) investigating the cellular and developmental mechanisms underlying animal responses to intracellular beneficial microbes. The research utilizes the sea anemone Aiptasia as a genetically tractable model organism to study the endosymbiotic...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $433,125 to the University of California, Los Angeles (UCLA) under the Biomedical Research and Research Training program (CFDA 93.859) to develop imaging-based molecular recording technology that reconstructs cellular signaling histories. The project, which commenced April 1, 2026 and extends through February 28, 2031, focuses on engineering CRISPR base editors to generate mutations in...
- Federal Grant Award Summary Molecular Instruments, Inc. received a $306,788 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with an award date of September 30, 2025 and completion date of September 29, 2026. The grant supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing Hybridization Chain Reaction (HCR) amplification methodology. The...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $119,907 under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project period (August 1, 2025 – July 31, 2027). This Project Grant funds fundamental research to advance understanding of TnpB, a compact transposon-encoded RNA-guided endonuclease with significant potential for genome-editing applications. The research delivers three primary products: (1) a...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $3.93 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 15, 2025, with completion targeted for July 31, 2029. The award supports the development of high-throughput quantitative phase microscopy (QPM) imaging systems based on customizable nano-optics to advance imaging cytometry capabilities....
The National Institute of General Medical Sciences (NIGMS) awarded Lawrence Berkeley National Laboratory $430,109 under the Biomedical Research and Research Training program (CFDA 93.859) beginning June 1, 2026, with completion targeted for March 31, 2030. This project grant supports the development and application of avalanching nanoparticles (ANPs) as advanced optical imaging probes for biomedical research. The primary deliverables include synthesis of biocompatible, antibody-functionalized ANPs optimized for receptor targeting in live-cell imaging, construction of a modified laser scanning confocal microscope system engineered to address photon avalanching kinetics, and demonstration of sub-70 nanometer spatial resolution imaging capabilities using near-infrared excitation. The research addresses critical limitations in current optical microscopy by leveraging ANPs' unique nonlinear emission properties to enable phototoxicity-free imaging with superior penetration depth and elimination of autofluorescence and photobleaching artifacts. The project will validate these optical advances through live-cell imaging studies of breast cancer cells and neural microglia, characterizing spatial localization and dynamics of cell surface receptors essential to cellular function. This fundamental research contributes to NIGMS's mission of advancing understanding of biological processes and establishing foundations for improved disease diagnosis and treatment methodologies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.1k | 5/12/26 |