Project Grant R01GM164302
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Massachusetts $539,219 on June 9, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop polymeric lysosome-targeting chimeras (POLYTACS), a biomaterials platform for cell-specific degradation of membrane proteins. The award funds research to create a versatile POLYTACS platform enabling targeted protein degradation of...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded Trustees of Boston University $449,625 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance targeted delivery of intracellular protein therapeutics using virus-like particles derived from retroviruses. The research focuses on developing design principles for next-generation virus-like particles (VLPs) that enhance cell-specific...
- The National Center for Advancing Translational Sciences awarded Trustees of Tufts College $749,732 on August 1, 2026, under the NCATS program (CFDA 93.350) to develop targeted lysosomal degradation of RNA as a new drug modality. The project develops "ribo-ATTECs," bifunctional compounds that harness RNA autophagy to degrade disease-causing RNAs by recruiting them to lysosomes for degradation by lysosomal RNases. This approach addresses limitations of existing targeted RNA...
- The National Institute of General Medical Sciences awarded the University of California Irvine $448,510 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop bifunctional small-molecule degraders that target the proteasome-mediated protein degradation pathway for cancer and protein accumulation diseases. The project will develop RPN-13-binding degraders, a new class of molecules that direct proteins of interest to the proteasome entrance without...
- The National Institute of General Medical Sciences awarded Trustees of Tufts College $391,999 on May 11, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate DNA damage tolerance strategies at the organismal level. The funded research examines mechanisms of genome instability caused by error-prone DNA repair and damage tolerance mechanisms, with specific focus on translesion DNA polymerases in double-strand break repair and lesion bypass. The...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Brigham & Women's Hospital Inc. $230,388 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop small molecule inhibitors of the E3 ligase NEDD4. The project consists of two research aims. Aim 1 investigates the structural dynamics of the NEDD4 HECT domain through NMR spectroscopy, using different...
- The National Institute of General Medical Sciences awarded Yale University $420,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes, chemistries, and probes for expanded proteomic and lipidomic analysis. The research addresses limitations in current proximity labeling applications, which create localized reactive intermediates to tag nearby proteins in their native cellular environment. Existing...
- The National Institute of General Medical Sciences awarded $498,000 to Trustees of Tufts College on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support research elucidating the epigenetic regulation of extracellular matrix and virus-induced fibroblast activation. The project investigates how epigenetic mechanisms control the sustained activation of fibroblasts into myofibroblasts during fibrotic disease, focusing on the role of BRG1...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,993,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemistry-driven tools for studying protein function through intein-mediated protein splicing. The research focuses on three major areas: exploitation and extension of protein transposition technology to replace designated internal regions of folded proteins or protein complexes with...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $650,000 to the Trustees of Tufts College on July 1, 2026, under the Engineering program (CFDA 47.041) to optimize codon usage in engineered HEK293 cells for sustained biopharmaceutical production. The work addresses cellular stress and genetic instability that occurs when mammalian cell lines overexpress recombinant proteins for vaccine and therapeutic manufacturing. Researchers...
The National Institute of General Medical Sciences awarded $1.243 million to Trustees of Tufts College on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop intracellular delivery approaches that overcome the hook effect in proteolysis-targeting chimera (PROTAC) technology and improve protein degradation efficiency. The project addresses a technical limitation in PROTAC-mediated protein degradation where elevated PROTAC concentrations saturate binding sites on either the target protein or E3 ligase without forming the essential ternary complex required for ubiquitination and subsequent proteasome-mediated degradation. Work spans three aims: covalent conjugation of ligands for target proteins onto E3 ubiquitin ligases; in vitro and in vivo study of lipid nanoparticle-mediated delivery of pre-fused E3P-PROTAC complexes; and in vivo study of PROTAC delivery for reversing liver fibrosis in a mouse model. The project will develop more efficient approaches for target protein degradation through the ubiquitin proteasome system and establish proof-of-concept that directly conjugating ligands for target proteins on E3 ligases is effective for protein degradation. Performance occurs in Boston, Massachusetts, with a period of performance from August 1, 2026, through July 31, 2030. Tufts, a major private research institution and prime recipient on federal grants across civilian and defense agencies, receives this funding as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/29/26 |