Project Grant R35GM163546
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for discovery and engineering of enzymes that modify amino acids and peptides for use as synthetic tools in biomedical research. The research develops methods to discover, characterize, and engineer enzymes and metabolic pathways involved in amino acid and peptide modification. The work focuses on...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,227,666 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support chemical approaches to investigating post-transcriptional RNA regulation through the Kleiner Group at Princeton. The funded research applies chemical biology, proximity labeling, and mass spectrometry methods to map and characterize the spatial distribution and subcellular dynamics of...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $165,366 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop photoenzymes for selective chemical synthesis. The research will engineer naturally occurring dark enzymes to function as photoenzymes—biological catalysts that use photonic energy to drive chemical reactions—to address selectivity challenges in radical organic chemistry. The work includes...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded $227,652 to The Trustees of Princeton University on June 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop stereoselective photoenzymatic methods for oxygen- and nitrogen-centered radical transformations mediated by pyridoxal 5'-phosphate cofactors. The project will leverage pyridoxal...
- The National Institute of General Medical Sciences (NIGMS) awarded $369,000 to Princeton University on June 1, 2026, under CFDA 93.859 (Biomedical Research and Research Training) to support optogenetic tools and biosensor development for studying intracellular signaling and cellular decision-making. The Toettcher Laboratory at Princeton will develop cutting-edge optogenetic tools and biosensors to probe and manipulate cells' internal states over the five-year performance period ending May 31,...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated experimental and computational platform for mapping, modulating, and modeling intercellular forces in living tissues. The research program establishes scalable technologies combining flexible microfabricated bioelectronic sensor-actuator devices, high-speed volumetric optical...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $225,564 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop light-driven deracemization methods for atropisomers using chiral photocatalysts. The research aims to create a broadly applicable strategy to convert readily available racemate compounds into enantiopure atropisomers through photocatalytic processes, enabling facile access to structural...
- Federal Project Grant Award Summary Princeton University's Office of Research and Project Administration has been awarded $1,968,575 through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) for a project titled "Computational Approaches for Elucidating Proteomes and Interactomes." The award, effective September 15, 2025, with completion scheduled for August 31, 2029, supports the development of advanced...
- The National Institute of General Medical Sciences awarded Princeton University $125,000 on August 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop activity-based probes for detecting and characterizing reactive oxygen species and aldehydes in living systems. The research focuses on developing chemoproteomic methods and activity-based probes to identify molecular targets of reactive oxygen species and aldehydes across the proteome, with emphasis on...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel computational and statistical methods for interpreting human genomic variation and to construct high-quality, haplotype-resolved de novo assembled genomes from individuals in understudied populations. The work encompasses methodological advances in phasing and accuracy of genomes...
The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,993,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemistry-driven tools for studying protein function through intein-mediated protein splicing. The research focuses on three major areas: exploitation and extension of protein transposition technology to replace designated internal regions of folded proteins or protein complexes with synthetic donor cassettes in a single coordinated process, applicable to both in vitro and in vivo protein editing; installation of biochemical probes and post-translational modifications into systems relevant to chromatin biology; and study of the role of post-translational modifications in regulating chromatin function, with particular focus on histone monoaminylation. This work represents a conceptual departure from previous protein chemical synthesis approaches by avoiding the need for a protein folding step following stepwise assembly of the primary sequence. Work is performed at Princeton, New Jersey, with a period of performance from September 1, 2026, through August 31, 2030. The award is classified as a Project Grant, a mechanism supporting investigator-initiated biomedical research to advance understanding of human health and disease through peer-reviewed scientific merit.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 8/14/26 |