Project Grant R01GM160648
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
- The National Institute of General Medical Sciences awarded Yale University $425,904 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define the conserved ancestral regulatory logic of animal cells and tissues. The research integrates multimodal single-cell profiling, functional perturbations, and novel imaging methods to decipher how genomes use a limited set of cell classes to generate different tissues across animal bodies. The laboratory...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $605,140 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate cellular and molecular mechanisms of lipid-mediated protein trafficking through the mammalian Golgi complex. The research investigates how palmitoylation in the early secretory pathway sorts proteins and accelerates their...
- Federal Grant Award Summary Yale University received a $2.31 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 8, 2025, with completion targeted for September 7, 2029. The research project, titled "Decoding the Molecular Choreography of Diverse Vesicle Release Mechanisms," will advance fundamental understanding of large dense-core vesicle (LDCV) fusion...
- Yale University received a $669,737 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for research on the mechanics of convective cell motion. The two-year project, which commenced September 1, 2025 and concludes August 31, 2027, supports fundamental basic research investigating how cellular populations move collectively through tissue-level mechanical forces such as surface tension and pressure...
- Federal Grant Award Summary Yale University received a $2.1 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports fundamental research investigating the biological role and pharmacology of the EXPERA family of membrane proteins, specifically sigma-2 receptor (TMEM97) and transmembrane 6 superfamily member 2 (TM6SF2),...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular and structural basis of glycoRNA-receptor interaction. The project will determine the chemical, biochemical, and structural bases of glycoRNA-P-selectin interactions, establishing this system as a model to dissect the molecular principles and physiological functions of RNA glycosylation....
- The National Institute of General Medical Sciences awarded Yale University $537,696 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate chromatin organization mechanisms in the germline and their role in directing embryonic development and differentiation. The research program uses genetic, molecular, and genomic tools to study epigenetic regulation in C. elegans germ cells, examining how remodeling of nucleosome positioning and histone...
- The National Institute of General Medical Sciences awarded Yale University $420,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes, chemistries, and probes for expanded proteomic and lipidomic analysis. The research addresses limitations in current proximity labeling applications, which create localized reactive intermediates to tag nearby proteins in their native cellular environment. Existing...
- The National Institute of General Medical Sciences awarded Yale University $2,014,434 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a synthetic biology tool that engineers proteins with multiple posttranslational modifications and elucidates their binding function. The project addresses the challenge that protein complexes differentiated by posttranslational modifications cannot be separated from non-modified complexes in mammalian...
The National Institute of General Medical Sciences awarded Yale University $1,420,575 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the molecular mechanisms regulating cellular force buffering and compartmental integrity. The research addresses the incomplete understanding of how cellular organelles—specifically the endoplasmic reticulum and nuclear envelope—maintain their characteristic morphology and structural integrity. The project investigates the role of the nodal modulator (NOMO) protein, an ER-resident transmembrane protein highly expressed in skeletal muscle, which assembles into force-buffering oligomers that experience piconewton-range intraluminal forces. The work combines biochemical, biophysical, and genetic approaches to test whether NOMO organizes into metastable, force-buffering assemblies that confer mechanical stability while remaining dynamic enough to permit normal secretion. Understanding these cellular networks has direct relevance to muscular disorders linked to compromised compartmental integrity. The award funds research at Yale University in New Haven, Connecticut, from September 1, 2026, through August 31, 2030. This is a Project Grant, the standard NIH research grant mechanism supporting investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 8/3/26 |