Project Grant R35GM166441
- The National Institute of General Medical Sciences awarded Yale University $537,696 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate chromatin organization mechanisms in the germline and their role in directing embryonic development and differentiation. The research program uses genetic, molecular, and genomic tools to study epigenetic regulation in C. elegans germ cells, examining how remodeling of nucleosome positioning and histone...
- The National Institute of General Medical Sciences awarded Yale University $462,000 in project grant funding on August 1, 2026, to study the regulation of tissue barriers during host-microbe interactions under the Biomedical Research and Research Training program (CFDA 93.859). The research combines single-cell and spatial genomics, biosensors, and genetic approaches across plant species to map the transcriptional and hormonal networks governing microbial colonization, immune activation, and...
- The National Institute of General Medical Sciences awarded Yale University $1,420,575 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the molecular mechanisms regulating cellular force buffering and compartmental integrity. The research addresses the incomplete understanding of how cellular organelles—specifically the endoplasmic reticulum and nuclear envelope—maintain their characteristic morphology and structural integrity. The...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
- The National Institute of General Medical Sciences awarded Yale University $420,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes, chemistries, and probes for expanded proteomic and lipidomic analysis. The research addresses limitations in current proximity labeling applications, which create localized reactive intermediates to tag nearby proteins in their native cellular environment. Existing...
- The National Institute of General Medical Sciences awarded Yale University $922,854 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop scalable statistical methods for inferring interactions within large biological networks and to apply these methods to neural activity and chromatin structure. The research will leverage recordings of thousands of neurons in the mouse hippocampus and visual system to identify networks of neural interactions...
- The National Institute of General Medical Sciences awarded Yale University $515,290 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to investigate the cellular recycling pathway termed RICE (recycling of internalized cilia by exocyst) and its role in ciliary disassembly during neuroprogenitor differentiation. The research centers on primary cilia—microtubule-based organelles that regulate cell fate during neurodevelopment—and the mechanism by which...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $605,140 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate cellular and molecular mechanisms of lipid-mediated protein trafficking through the mammalian Golgi complex. The research investigates how palmitoylation in the early secretory pathway sorts proteins and accelerates their...
- Yale University received a $669,737 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for research on the mechanics of convective cell motion. The two-year project, which commenced September 1, 2025 and concludes August 31, 2027, supports fundamental basic research investigating how cellular populations move collectively through tissue-level mechanical forces such as surface tension and pressure...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
The National Institute of General Medical Sciences awarded Yale University $425,904 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define the conserved ancestral regulatory logic of animal cells and tissues. The research integrates multimodal single-cell profiling, functional perturbations, and novel imaging methods to decipher how genomes use a limited set of cell classes to generate different tissues across animal bodies. The laboratory leverages the freshwater sponge Spongilla lacustris as a model organism to dissect the conserved regulatory principles underpinning cell and tissue identity. Over the five-year performance period, the work will determine the transcriptional mechanisms that encode cell identity, investigate how cell class identity shapes responses to developmental signals, and test the hypothesis that modular regulatory circuits instruct assembly of distinct cellular structures. The outcome targets an unprecedented systems-level understanding of the conserved regulatory principles and earliest evolutionary origins of animal cell and tissue variation. Performance occurs at Yale University in New Haven, Connecticut from September 1, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $425.9k | 8/26/26 |