Federal Project Grant Award Summary

The National Institute of General Medical Sciences (NIGMS) awarded $343,007 in Project Grant funding on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a research initiative titled "Characterizing Glycosylation Regulatory Networks Using Single-Cell Multiomics and Mathematical Modeling." The Research Foundation for the State University of New York, serving as the fiscal agent, administers the award for research conducted in Buffalo, NY, with an ultimate completion date of March 31, 2030.

This project will deliver integrated research products and outputs aimed at systematically characterizing how glycosylation—a critical post-translational modification affecting cellular function—is regulated in mammalian systems. The research team will generate single-cell multi-omics datasets (epigenomics, transcriptomics, and glycomics profiles) from hematopoietic stem cell differentiation studies, catalog transcriptional regulators of glycosylation genes through bioinformatics analysis, and develop both mechanistic and deep learning-based computational models to identify key regulatory networks governing glycan biosynthesis. These research outputs will advance fundamental understanding of glycosylation regulatory mechanisms and provide a foundation for future biomedical applications in disease diagnosis and treatment.