Project Grant R01GM158926
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- The University of Texas Health Science Center at San Antonio (UTHSCSA) was awarded a $385,639 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds research aimed at uncovering the molecular details behind synaptic transmission, with a focus on understanding the structure and function of AMPA receptor complexes in the brain. The research project, scheduled to run from September 1,...
- This federal Project Grant award, valued at $758,594 and spanning from September 1, 2025 to August 31, 2027, was provided by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the molecular basis of the TREX-2 mRNA nuclear export pathway. The research aims to elucidate the differential roles and interaction networks of the TREX-2...
- The University of Pennsylvania was awarded a $443,806 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research investigating the collective impacts and regulatory mechanisms of multiple enzyme-mediated modifications across distinct RNA species, particularly in the areas of mRNA, tRNA, and rRNA. The research aims to uncover the extent of crosstalk in...
- This federal Project Grant award of $398,444, awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to systematically dissect the contributions of the cellular environment on the polymodal regulation of transient receptor potential (TRP) ion channels. The University of Texas at San Antonio (UTSA) will conduct cell-based experiments and in vitro reconstitution...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $390,000.00 to the University of Texas Health Science Center at Houston (UTHealth) for research focused on understanding how "proppins" (B-propellers that bind phosphoinositides) differentially regulate basal autophagy, a key cellular process, across distinct tissue types and developmental stages. The research...
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- The University of Houston System was awarded a $435,412 Project Grant from the National Institutes of Health (NIH) under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a new technology for whole-genome sequencing of RNA-DNA triplexes. The project aims to capture and characterize these novel RNA-DNA structures, which have important regulatory functions but are challenging to study using current methods. The core of the new technology, called...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- The University of Texas Southwestern Medical Center (UT Southwestern) received a $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms underlying purine salvage regulation in response to suppressed oxidative phosphorylation (OXPHOS) in macrophages. The overarching objective is to elucidate how OXPHOS suppression potentiates purine...
The University of Texas Health Science Center at Houston (UTHealth) was awarded a $868,584 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, which runs from September 1, 2025 to August 31, 2027, will fund research to investigate how RNA modifications regulate adaptive mRNA translation. The research aims to elucidate the roles of the TRMT1L RNA methyltransferase and its interaction with the RIX1 ribosome biogenesis complex in establishing mRNA translational programs in response to cellular stress. This research could provide critical insights into the regulation of tRNA modifications and their importance for maintaining normal cellular physiology and preventing disease development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $868.6k | 8/28/25 |