Project Grant R01GM155589
- The National Institute of Neurological Disorders and Stroke awarded Yale University $583,646 on March 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cilia disassembly and dysfunction in malformations of cortical development. Malformations of cortical development are neurological disorders characterized by altered organization and function of cortical neurons, often resulting in intractable epileptic...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded Rutgers, The State University $113,205 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how mechanical force causes cilia to shed extracellular vesicles. The research examines mechanically induced extracellular vesicle shedding from cilia using Caenorhabditis elegans males as a model system. The project addresses three specific aims: determining which physiological stimuli elicit...
- The National Institute of General Medical Sciences awarded Yale University $537,696 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate chromatin organization mechanisms in the germline and their role in directing embryonic development and differentiation. The research program uses genetic, molecular, and genomic tools to study epigenetic regulation in C. elegans germ cells, examining how remodeling of nucleosome positioning and histone...
- The National Institute of General Medical Sciences awarded Yale University $425,904 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define the conserved ancestral regulatory logic of animal cells and tissues. The research integrates multimodal single-cell profiling, functional perturbations, and novel imaging methods to decipher how genomes use a limited set of cell classes to generate different tissues across animal bodies. The laboratory...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $556,694 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and functional analysis of ciliary complexes, with work performed in Dallas, Texas through March 31, 2031. The award funds an integrated research program combining structural cell biology, disease-focused analysis, and technical innovation to advance...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular and structural basis of glycoRNA-receptor interaction. The project will determine the chemical, biochemical, and structural bases of glycoRNA-P-selectin interactions, establishing this system as a model to dissect the molecular principles and physiological functions of RNA glycosylation....
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $605,140 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate cellular and molecular mechanisms of lipid-mediated protein trafficking through the mammalian Golgi complex. The research investigates how palmitoylation in the early secretory pathway sorts proteins and accelerates their...
- The National Institute of General Medical Sciences, under the Department of Health and Human Services National Institutes of Health, awarded the University of Delaware $392,495 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of extracellular vesicle biogenesis and uptake. The research examines how cells release distinct extracellular vesicle subpopulations and how those vesicles mediate intercellular transport of bioactive...
The National Institute of General Medical Sciences awarded Yale University $515,290 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to investigate the cellular recycling pathway termed RICE (recycling of internalized cilia by exocyst) and its role in ciliary disassembly during neuroprogenitor differentiation. The research centers on primary cilia—microtubule-based organelles that regulate cell fate during neurodevelopment—and the mechanism by which post-mitotic cells dismantle them. In the RICE pathway, cilia undergo internalization into the cytoplasm, transit through phosphoinositide-enriched membrane compartments, and reappear on the cell surface through exocyst-mediated trafficking, with each cycle resulting in progressive cilium shortening as the signaling-rich tip sheds. Aim 1 will define the physiological role of RICE in neuroprogenitor differentiation and determine how its disruption contributes to microcephaly, a severe neurodevelopmental disorder linked to multiple human exocyst gene mutations. Aim 2 will dissect the molecular mechanisms regulating RICE, including phosphoinositide signaling, septin remodeling, and exocyst-dependent trafficking. The project integrates advanced imaging approaches, including live-cell microscopy and high-resolution cilia assays, and runs through June 30, 2030, with performance at Yale University's New Haven, Connecticut location.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $515.3k | 7/24/26 |