Project Grant K99GM166850
- The National Institute of General Medical Sciences, under the Department of Health and Human Services National Institutes of Health, awarded the University of Delaware $392,495 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of extracellular vesicle biogenesis and uptake. The research examines how cells release distinct extracellular vesicle subpopulations and how those vesicles mediate intercellular transport of bioactive...
- The National Institute of General Medical Sciences awarded Rutgers, The State University of New Jersey $533,456 on July 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to support research on regulation of PIEZO2 and TRPV6/5 ion channels. The funded research defines the molecular basis of phosphatidic acid and lysophosphatidic acid inhibition of the mechanically-activated PIEZO2 ion channel and interrogates how phospholipase-D and diacylglycerol-kinase...
- The National Institute of General Medical Sciences awarded Yale University $515,290 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to investigate the cellular recycling pathway termed RICE (recycling of internalized cilia by exocyst) and its role in ciliary disassembly during neuroprogenitor differentiation. The research centers on primary cilia—microtubule-based organelles that regulate cell fate during neurodevelopment—and the mechanism by which...
- The National Institute of General Medical Sciences awarded Rutgers, The State University $487,500 under the Biomedical Research and Research Training program (CFDA 93.859) on May 11, 2026, to investigate the mechanisms of adaptive immunity in RNA-targeting CRISPR-Cas13 systems. The research uses microbiological, genetic, high-throughput sequencing, biochemical, and structural analyses to systematically examine collateral RNA cleavage activity across a broad panel of Cas13 homologs representing...
- The National Institute of General Medical Sciences awarded Rutgers, The State University of New Jersey, Newark Division $431,750 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular determinants of physiological stress granule homeostasis and function. The research examines stress granules—cytoplasmic structures cells form to store non-translating messenger RNAs during stress—with emphasis on axonal stress granules in peripheral...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded The Research Foundation For The State University Of New York (Stony Brook University) $432,569 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the regulatory mechanisms of extracellular particle-mediated intercellular signaling. The research deciphers how cells release extracellular particles containing biomolecules to establish non-contact communication with neighboring or...
- The National Institute of General Medical Sciences awarded Rutgers, The State University $383,511 on August 1, 2026, as a Project Grant (CFDA 93.859, Biomedical Research and Research Training) to investigate microbial modulation of insect sensory plasticity. The research establishes a framework for understanding how microbes and microbial products regulate insect sensory plasticity and how these interactions are influenced by environmental context and microbial metabolites. The work integrates...
- The National Institute of General Medical Sciences awarded Cornell University $437,344 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate bacterial extracellular vesicles as mediators of bacterial-bacterial and bacterial-human cell communication. The research examines how bacterial extracellular vesicles facilitate transport of protein cargo across the mucosal barrier to host cells and distant body sites, with potential applications...
- The National Institute of General Medical Sciences awarded Rutgers The State University of New Jersey $431,750 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support five years of research on internal N7-methylguanosine (m7G) modification in RNA metabolism through September 30, 2031. The research investigates how internal m7G—a recently discovered RNA modification positioned within mRNA transcript bodies—regulates RNA metabolism and gene...
The National Institute of General Medical Sciences awarded Rutgers, The State University $113,205 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how mechanical force causes cilia to shed extracellular vesicles. The research examines mechanically induced extracellular vesicle shedding from cilia using Caenorhabditis elegans males as a model system. The project addresses three specific aims: determining which physiological stimuli elicit ciliary extracellular vesicle shedding; investigating how ciliary membrane composition primes cells for force-induced shedding; and determining how molecular regulation of membrane curvature impacts shedding. The work uses live super-resolution imaging to observe shedding dynamics. Research findings will provide insight into how cells respond to mechanical environments and how extracellular vesicles transmit environmental information to other cells, with implications for understanding ciliopathies and developing extracellular vesicle-based clinical applications. Performance of research takes place in Piscataway, New Jersey. The period of performance runs from August 1, 2026, through July 31, 2028. This is a Project Grant, a form of assistance funding supporting investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $113.2k | 7/30/26 |