The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,226,250.00 to The University of Texas M.D. Anderson Cancer Center to investigate the role of DNA methylation in controlling retrotransposons and governing adult stem cell fates. The 5-year award, running from August 1, 2024 to May 31, 2029, will examine how DNA methylation regulates retrotransposons and impacts adult stem...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) totals $408,750 and is effective from September 15, 2024 through July 31, 2029. The award will support the development of large-scale composite hypothesis testing approaches for performing translational genetics analyses. Specifically, the research will focus on creating interpretable and robust statistical methods for...
This $1,380,568 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant is funding a 5-year interdisciplinary research project to develop a multiscale, predictive understanding of how cells adapt to changes in their environment. The key research thrusts include: 1) studying the adaptive roles of stress-induced biomolecular condensates in...
This federal Project Grant award, valued at $1,675,000.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on understanding the mechanisms that control regulated cell death (RCD). The primary objectives of this 5-year project are to: 1) identify the mechanisms of regulation and coordination between apoptotic and non-apoptotic forms of cell death, 2) explore the...
This $534,160.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The key objectives are to elucidate the mechanisms of ion recognition and transport across membranes, as well as how the activities of these proteins...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $412,500.00 to the University of South Florida (USF) for a research project titled "Molecular and Chemical Regulation of Cell Death in Disease." The research aims to elucidate the mechanisms of programmed cell death pathways, specifically apoptosis and necroptosis, and develop inhibitors to treat...
This federal Project Grant award, valued at $1,117,764.00 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at understanding the mechanisms that govern cell fate decisions. The overarching goal is to unveil the interplay between two distinct signals that regulate B cell fate, with a focus on how metabolic processes and mitochondrial function influence the decision between...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,334,586.00 to The University of Texas Southwestern Medical Center to investigate the cardiovascular and thermoregulatory consequences of severe burn injuries in humans. The primary objectives are to extend current understanding of the adverse impacts of severe burns on cardiovascular function and the body's ability to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $959,190 in funding to the University of North Carolina at Charlotte (UNC Charlotte) to investigate the role of HSP70 protein phosphorylation in proteostasis. The research aims to study how phosphorylation of the HSP70 molecular chaperone impacts its function in the heat shock response and cell integrity signaling pathways...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,470,366 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas MD Anderson Cancer Center in Houston, TX. The grant, which runs from August 15, 2024 to May 31, 2028, will fund research to investigate the noncanonical roles of the protein BIM in regulating lysosomal trafficking and its impact on heat shock-induced cell death. The goal is to provide insights into the mechanisms by which heat shock leads to cell death, with implications for understanding and treating conditions like heatstroke as well as exploring the use of localized hyperthermia in cancer treatment. The research will focus on determining the roles of BIM in lysosome number and positioning, heat shock-induced lysosomal membrane permeabilization and exocytosis, the contribution of nuclear cathepsin L, and the in vivo effects of BIM in mouse models of localized and whole-body hyperthermia.