Project Grant R01GM154887

Award Date 9/1/24
Completion Date 6/30/29
Dollars Obligated $700K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Dallas, TX 75390, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $1,215,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas M.D. Anderson Cancer Center. The grant, effective September 1, 2024 through July 31, 2029, will support a functional analysis of arginine methylation, a common post-translational modification. The research aims to broadly understand the biological roles of arginine methylation, identify novel effector proteins that...
This Project Grant award of $562,800.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to determine whether pseudoenzymes from various enzyme superfamilies exhibit catalytic activity and potentially catalyze novel chemical transformations. The research aims to uncover unexpected post-translational modifications for pseudoenzymes, which could yield vital mechanistic insights into disease...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $117,499.00 to the University of Utah to investigate a novel regulatory pathway involving a cyclic AMP (cAMP)-responsive riboswitch in the 5'UTR of the COX7B gene. The overarching objective is to characterize how this riboswitch impacts the function of complex IV in the electron transport chain and overall cellular...
The National Institute of General Medical Sciences (NIGMS) awarded a $925,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The grant supports a multidisciplinary research program to discover chemical modulators of RNA-protein assemblies, with a focus on targeting Dead-box RNA-dependent ATPases. The project aims to identify allosteric compounds that stabilize Dead-box protein-RNA interactions, optimize...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $321,484 Project Grant to the University of Texas at Austin. The grant, effective May 1, 2025 through April 30, 2030, will support research to uncover the fundamental role of extracellular electron transfer (EET) in human health and apply this knowledge to develop new therapeutics and biological catalysts. Key objectives include engineering electron...
The National Institute of General Medical Sciences (NIGMS) awarded a $274,597 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The 5-year grant, effective August 1, 2025, supports research on proteomic and phosphoproteomic remodeling under genomic imbalance, or aneuploidy. The project aims to study the mechanisms of protein regulation and signaling pathways in aneuploid cells, with a focus on distinguishing the effects of chromosome gain...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $762,960 to the University of Texas at Austin to develop localized real-time sensors for monitoring intracellular metabolic signaling. The research aims to deconvolute the signaling roles of metabolites by creating genetically encoded fluorescent biosensors that can measure specific metabolite concentrations and fluctuations within...
This Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will provide $410,000.00 to The University of Texas Southwestern Medical Center to conduct research on the regulation of the phosphate transporter SLC20A1. The research aims to examine the mechanisms governing SLC20A1 internalization, degradation, recycling, and synthesis in order to better understand phosphate sensing and homeostasis in...
This $228,340 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the role of endoplasmic reticulum (ER)-to-actin tethering in cell migration, a critical process for tissue development and repair. The research aims to determine the mechanisms by which the ER interacts with the actin cytoskeleton and spatially coordinates ER-actin...
The National Institute of General Medical Sciences (NIGMS) awarded a $645,712 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Trustees of Tufts College in Medford, MA. The grant supports the development of new chemical biology tools to study protein post-translational modifications, specifically glycation and ubiquitination, in living cells. The research aims to uncover how these modifications are integrated into cellular signaling networks and...

The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) in the amount of $699,830.00 to The University of Texas Southwestern Medical Center (UT Southwestern), effective September 1, 2024 through June 30, 2029.

The grant supports research to determine the biochemical and molecular mechanisms of RNASE Z-mediated deampylation, a novel post-translational modification involving the covalent addition of adenosine monophosphate (AMP) to proteins in the mitochondria. The research aims to elucidate the functional importance of ampylation and the enzymes that regulate this process, which has implications for understanding diseases associated with RNASE Z mutations such as hypertrophic cardiomyopathy and prostate cancer. The project will leverage a novel enrichment strategy developed by the researchers to identify and characterize ampylated proteins in the mitochondria.

Generated 8/5/25, 4:42 AM