The Research Foundation for the State University of New York (SUNY) received a $400,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under CFDA 47.074 - Biological Sciences. The project aims to improve understanding of the DNA mismatch repair (MMR) pathway and how changes in the behavior of mismatch repair proteins can lead to genome instability, particularly in the presence of specific DNA sequences like repetitive elements. Key project...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $144,362.00 to The Research Foundation For The State University Of New York to investigate the mechanism of Ess1-mediated regulation of the CTD of RNAP II phase separation. The project will be conducted at the Upstate Medical Center in Syracuse, NY and is expected to be completed by April 30, 2025. This research aims to...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), provides $1,350,554.00 to the Sloan-Kettering Institute for Cancer Research to conduct research on the molecular mechanisms of eukaryotic chromosome replication. The research aims to illuminate both the intrinsic mechanism of the eukaryotic DNA replication machinery and its response to diverse replication stress conditions, with...
This $1,203,701 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to improve drug development by evaluating aspects of the drug development process. The award recipient, The Research Foundation For The State University Of New York, will utilize protein kinase inhibitors, specifically novel ATP-allosteric bivalent inhibitors (AABIs), to: Selectively target the inactive state of human...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, will provide $401,914 to The Research Foundation For The State University Of New York over a 5-year period from February 2025 to January 2030. The funding will support research to elucidate the evolutionary, biomedical, and functional impact of genomic structural variations (SVs) - large deletions, duplications, inversions, and...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research into the molecular mechanisms of DNA replication during mitosis. The award, effective December 17, 2024 through November 30, 2029, will enable researchers at the University of Colorado-Denver to use biochemical reconstitution and yeast genetics approaches to investigate how the replication machinery is regulated...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $389,653 to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany to develop a transdisciplinary research program focused on AI-supported biosensing and precision therapeutics using DNA nanotechnology and synthetic biology. The key products/services to be delivered include: (1) a synthetic biology...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...
This $2,285,694 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Tufts University to study the relationship between DNA replication and tandem repeat instability. The grantee will combine genetic assays and single-cell live microscopy analysis in a model system to understand how repeat length changes during replication. This dual approach will examine how a repeat's length, propensity to form DNA structures, and orientation...