The National Institute of General Medical Sciences (NIGMS) awarded a $401,914 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF SUNY). The 5-year grant, which commenced on February 1, 2025, will support research into the evolutionary and functional impact of common genomic structural variations. Specifically, the project will investigate the mutational mechanisms shaping structural variants, the evolutionary processes maintaining functional structural variants, and the effects of different structural variant types on biological function. This research aims to provide novel insights into the mechanistic basis linking structural variation to biological function and disease risk. The project will leverage a range of approaches, including evolutionary genomics, in vivo models, and functional genomics datasets. RF SUNY may also issue sub-awards to collaborate with other institutions on this research.
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