This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel imaging technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. This 5-year research program, starting on August 15, 2024, seeks to enable simultaneous functional and structural imaging...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
This $526,451 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel optical microscopy modality for cell biomechanics research. The primary objectives are to: Implement technical innovations to maximize the throughput of stimulated Brillouin scattering (SBS) microscopy, achieving a 100-fold improvement in acquisition speed compared to current state-of-the-art....
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $330,076 in funding to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The funding supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This advanced optical system will enable non-destructive profiling and mapping...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training aims to establish proof-of-concept for a new high-speed, real-time feedback-driven single particle tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The $410,014 project, with a period of performance from February 1, 2025 to January 31, 2027, will create a novel tracking approach that leverages...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will develop a novel micro-capsule technology to enable high-throughput analysis of millions of live cell-cell interactions in parallel. The $665,616 award to President and Fellows of Harvard College, doing business as Harvard Medical School, will establish two prototype methods to screen and map cell interactions at a scale 100-10,000...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...