This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting research to investigate the mechanism by which the endoplasmic reticulum (ER) chaperone GRP94 assists in the folding and secretion of insulin-like growth factor (IGF) proteins. The $433,342 award to Brandeis University aims to determine how the GRP94 chaperone operates with the BIP chaperone to properly fold IGF proteins,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $148,568 to the University of Massachusetts to investigate the interactions of the enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) with its substrates and co-chaperone. The goal is to utilize cellular and biophysical experiments to gain structural insights into the concerted action of UGGT and its co-chaperone protein Sep15...
The National Institute of General Medical Sciences (NIGMS) awarded a $645,712 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Trustees of Tufts College in Medford, MA. The grant supports the development of new chemical biology tools to study protein post-translational modifications, specifically glycation and ubiquitination, in living cells. The research aims to uncover how these modifications are integrated into cellular signaling networks and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, will support the University of Southern California's research program focused on "Chemistry-Enabled Glycoscience". The $342,342 award, with a project period from July 1, 2025 to June 30, 2030, will enable the development and application of chemistry-based approaches to study glycosylation and its effects on...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will provide $390,000 to Georgia State University Research Foundation Inc. over a 5-year period starting February 1, 2025. The funding will support the development of a small molecule-based platform to map the reader proteins of glycosylation, which play critical roles in cell-cell communication, tumor metastasis, and...
This federal Project Grant award of $644,900.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on PAS (Period-ARNT-Single-Minded) domain proteins. The research aims to obtain mechanistic insights into how these ubiquitous signaling proteins, found across all kingdoms of life, detect and respond to changes in environmental conditions. Specifically, the research will utilize...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $425,803 to The University of Mississippi to elucidate the structural attributes and functions of the cytosolic heat shock protein 70 (HSP70) and its role in maintaining cellular integrity and stress response. The research aims to investigate HSP70's lectin-like capacity to bind O-GlcNAcylated proteins, its ability to bind...
The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $471,019 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation (Georgia Tech Research Corp) to characterize extracellular glycoproteins and study their functions. The project aims to develop innovative mass spectrometry-based methods to comprehensively analyze glycoproteins on cell surfaces and in the secretome, as well as investigate the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,275 to the University of New Mexico Health Sciences Center (UNM HSC) from July 1, 2025 to June 30, 2030. The project aims to investigate the molecular mechanisms by which extracellular glucose levels regulate cell mechanics and function across different cell types. Key research objectives include elucidating the...