This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to improve the quality of cryogenic electron microscopy (cryo-EM) specimens. The $349,999 award to Denovx, LLC will fund research to develop innovative surface modifications for cryo-EM specimen supports that enhance the adsorption and random orientation of biological analytes, such as proteins and protein complexes. The researchers will...
The National Institute of General Medical Sciences (NIGMS) has awarded a $344,400 project grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new techniques to improve cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging. Specifically, the project aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological specimens, thereby...
This $386,190 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at Rensselaer Polytechnic Institute (RPI) focused on developing self-assembled multifunctional biointerfaces. The research aims to create hierarchically structured biomimetic materials and processes that can transform the properties of a wide range of substrates under biocompatible conditions. Key objectives...
The National Institute of General Medical Sciences (NIGMS) awarded a $947,705 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Applied Biophysics, Inc. in Troy, NY. The grant, running from July 2024 to June 2026, aims to develop an innovative "Cell Assurance Monitor" (CAM) instrument. This device will leverage impedance-based cellular monitoring and multivariate statistical analysis to assist researchers in detecting cell line...
This Project Grant award, with a total funding amount of $276,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award was granted to the Scripps Research Institute, a nonprofit biomedical research organization, to develop innovative graphene grid technologies that can overcome challenges posed by the air-water interface during cryogenic electron microscopy (cryoEM) sample...
This $374,399 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of innovative two-photon microscopy systems with scattering correction capabilities for deep tissue imaging. The University of California, Davis aims to develop high-speed, high-efficiency light modulation hardware and deep learning-based algorithms to optimize light propagation through scattering biological...
This $1,200,000 Project Grant awarded by the National Science Foundation (CFDA 47.074 - Biological Sciences) will support The Trustees of Columbia University in the City of New York in developing a time-resolved cryo-electron microscopy (cryo-EM) method to study the dynamics of biological molecules, including RNA polymerase, GLP1R, and the multi-drug efflux transporter AcrB. The research aims to broaden the application of this technique to expand understanding of molecular interactions in...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $291,224 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel biological imaging technology that combines the wavelength specificity of optical microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. The goal is to enable simultaneous functional imaging of molecules/proteins and structural imaging of...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This $372,100 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, effective from February 1, 2025 to January 31, 2030, supports the development of novel "mechanoimaging" technologies that convert receptor-level forces into visible light fluorescence. The goal is to quantify and control receptor-level forces in viscoelastic materials, which is a fundamental...