Project Grant R01GM152494
Award Date
9/20/24
Completion Date
6/30/28
Dollars Obligated
$356K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92697, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $363,384 to Duke University to develop computational tools to address key challenges in analyzing in situ spatial transcriptomics data. The project aims to:
Develop a framework for optimized cell segmentation that integrates RNA spatial location and imaging data, leveraging the latest segmentation algorithms. This will be...
This $509,982 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to unravel the fundamental mechanisms governing cell-cell communication and signal exchange during animal development. The research, led by the University of Maryland, College Park, will focus on investigating a specialized cell signaling mechanism called cytonemes, which enable polarized delivery of...
The University of California Irvine will use a $2.83 million project grant from the Department of Health and Human Services' National Institute of General Medical Sciences to decipher the mechanism of long-range gene regulation in vivo. Over a three-year period ending August 2025, UC Irvine researchers will utilize efficient enhancer replacement technology in mice to systematically characterize long-range enhancer activity and identify cis-regulatory sequences critical to this function. A...
The National Institute of General Medical Sciences (NIGMS) awarded a $767,510 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of North Carolina at Chapel Hill, effective July 9, 2024 through April 30, 2029. The grant will support research to study how alternative splicing of RNA impacts key cellular processes such as cytoskeleton dynamics, local translation, and transcriptional regulation, particularly in large, highly specialized cells like...
This $139,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) 93.859 Biomedical Research and Research Training program will support research by The Regents of the University of California, San Francisco (UCSF) to determine how the 3D spatial arrangement of signaling molecules affects T cell behavior and activation. The objective is to use DNA origami to pattern ligands with nanoscale precision and study the impact on intracellular signaling pathways, T cell...
The University of California Irvine received a $2,709,000 Project Grant from the Department of Health and Human Services Assistant Secretary for Financial Resources under the Biomedical Research and Research Training program (CFDA 93.859) for the period of September 1, 2022 through August 31, 2025.
The grant will support the development of a new RNA mapping tool called SMOOTHY-FISH that enables spatially mapping RNA molecules in individual cells with single nucleotide specificity and minimum...
The University of California, Irvine was awarded a $380,540 Project Grant from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant, titled "Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools," aims to address major knowledge gaps in the regulation, structural components, and substrate specificities of lysosomal proteins. The research will...
The National Institute of General Medical Sciences (NIGMS) awarded a $854,004 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Regents of the University of California, doing business as University of California, Berkeley. The grant, which runs from June 1, 2024 to April 30, 2029, will fund the development of computational tools to analyze ancestral recombination graphs and provide methods for testing hypotheses about the distribution and evolution of genomic...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), is providing $1,111,812 to the University of California Irvine to develop methods for improving the efficiency of unnatural metabolic cofactor technology. The research aims to make this technology more accessible to the bioengineering community and apply it to address difficult biosynthesis challenges. Key...
This $118,904 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to reveal signal transduction mechanisms in cellular signaling proteins. The research aims to use protein design and engineering techniques to generate tunable, modular versions of signaling protein subdomains and incorporate them into natural scaffolds. This will allow direct assessment of how changes...