This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $363,384 to Duke University to develop computational tools for analyzing in situ spatial transcriptomics data. The key products and services to be delivered under this 5-year award include:
- Developing a framework for optimized cell segmentation that integrates RNA spatial location and imaging data, using the latest segmentation algorithms.
- Establishing a framework for cell clustering and cell type annotation for in situ spatial transcriptomics data, by blending gene expression, cell morphology, and cell density information.
- Developing a flexible method to study cellular microenvironments, considering diverse cell types, molecules, and cell-cell interactions based on spatial proximity.
These computational tools aim to address key challenges in accurately identifying cell boundaries, distinguishing cell clusters and types, and understanding cellular interactions in spatial transcriptomics data. The award began on August 1, 2024 and is scheduled for completion by June 30, 2029.
Generated 1/28/25, 10:39 AM