Project Grant R01EY038525
- Federal Grant Award Summary The University of Alabama at Birmingham received a $636,862 Project Grant from the National Eye Institute's Vision Research program (CFDA 93.867) effective April 1, 2026, through March 31, 2030. This research initiative focuses on developing and validating mechanical, vascular, and morphometric biomarkers to assess individual eye-specific susceptibility to glaucoma onset and progression. The project will deliver longitudinal optical coherence tomography (OCT)...
- Federal Grant Award Summary Emory University received a $248,909 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2028. This award supports fundamental research investigating metabolic changes in retinitis pigmentosa (RP), an inherited form of vision loss caused by mutations in over 100 distinct genes. The project will deliver empirical findings on how energy metabolism is disrupted during photoreceptor...
- Federal Grant Award Summary The National Eye Institute (NEI), administering funds under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore a $249,000 Project Grant effective September 30, 2025, with completion targeted for August 31, 2028. This research project will develop and validate novel fluorescence lifetime imaging technologies to assess the retinal pigment epithelium (RPE) cell mosaic in the living human eye by characterizing intracellular pigment...
- Federal Project Grant Award Summary The Doheny Eye Institute received a $3,046,866 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2028. The award funds research on the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy (DR), a leading cause of vision loss in the working-age population. The research aims to deliver empirical findings and therapeutic insights...
- Federal Grant Award Summary The University of Mississippi Medical Center received a $693,423 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 15, 2025, with a completion date of August 31, 2026. The award funds development of a multivalent antibody cocktail designed to prevent and treat bacterial endophthalmitis, an eye infection that can occur following ocular surgery, trauma, or injections. The primary deliverables include a...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Project Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $504,304 Project Grant to Tufts University School of Medicine on April 15, 2026, with a project completion date of March 31, 2031. The award supports research investigating the mechanistic basis of the gut-retina axis and its relationship to age-related macular degeneration (AMD) prevention. Research Products and Services: The project will deliver...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $414,711 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded June 1, 2025, with completion targeted for May 31, 2029. The award supports the development and utilization of a microphysiological system to elucidate mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and...
The University of Alabama at Birmingham received a $668,581 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2030. This research initiative investigates the role of bacterial-derived metabolites in diabetic retinopathy (DR), with emphasis on tryptophan metabolites generated by the gut microbiome. The project will utilize liquid chromatography-mass spectrometry (LC-MS) for targeted metabolomics to identify protective and deleterious microbial metabolites in diabetic individuals, building upon preliminary findings demonstrating that indole 3-propionic acid (IPA) prevents DR development in type 2 diabetes mouse models by activating pregnane X receptor pathways and suppressing inflammatory signaling. The research products will include empirical findings characterizing the differential microbial metabolite profiles between diabetic retinopathy and non-retinopathy populations, mechanistic data on how bacterial-derived metabolites modulate intestinal and retinal barrier function through immune pathway suppression, and potential translational therapeutic targets for DR intervention. This fundamental and translational research addresses the NEI's mission to eliminate vision loss through innovative understanding of disease mechanisms and prevention strategies, contributing to the broader vision research portfolio focused on preventing and treating vision diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.6k | 4/2/26 |