Project Grant R01EY037299

Award Date 7/1/25
Completion Date 3/31/30
Dollars Obligated $617K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Georgia, USA
Similar Awards
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $628,531 to the University of Miami to validate and implement an artificial intelligence machine-to-machine (M2M) model for equitable glaucoma screening in underserved populations. The M2M model aims to provide objective, quantitative assessments of glaucomatous damage from low-cost fundus photography, overcoming limitations of existing imaging technologies. The project will refine the M2M...
Aisight Health Inc. received a $479,580 Project Grant award from the National Institutes of Health's National Eye Institute to develop artificial intelligence tools to identify rapid glaucoma progression. The goal is to use machine learning models trained on over a decade of optical coherence tomography images, visual field tests, and clinical records for more than 9,000 glaucoma patients to more accurately and quickly determine which patients are likely to experience rapid vision loss from...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting the development of equitable deep learning models for automated glaucoma screening. The $754,779 award, with a performance period from Sep 30, 2024 to Jul 31, 2029, aims to assess the performance equity of existing deep learning models, develop identity-conditioned generative models to improve data equality, and create fair identity normalization techniques to equalize...
This federal Project Grant award of $715,098 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to enhance glaucoma risk prediction through advanced genomics and machine learning. The key products and services to be delivered include: Improving polygenic risk score (PRS) performance for glaucoma by leveraging natural language processing techniques and electronic health record data from over 68,000 patients to extract refined glaucoma phenotypes. The...
This $185,000 Project Grant award from the National Eye Institute (NEI) under CFDA 93.867 (Vision Research) supports research to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The primary awardee, the University of North Texas Health Science Center at Fort Worth, will employ computational pharmacology approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP protein-protein interaction, a key pathogenic mechanism contributing...
The National Eye Institute (NEI), through its Vision Research federal grant program (CFDA 93.867), awarded a $679,159 Project Grant to The Schepens Eye Research Institute, Inc. in Boston, Massachusetts. The grant, awarded on May 1, 2025, supports research aimed at understanding how aging and elevated intraocular pressure (IOP) contribute to the development of glaucoma and impact retinal ganglion cells (RGCs). The research project will investigate the transcriptomic changes in RGCs due to aging...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $784,641 to the Georgia Tech Research Corporation from September 1, 2024 to June 30, 2029 to study the molecular mechanisms underlying trabecular meshwork cell death in glaucoma. The project aims to use a yeast model to screen for gene products and pathways that contribute to the cytotoxicity of mutant myocilin protein, a key genetic driver of early-onset glaucoma. The expected outcomes include...
This federal Project Grant award of $387,428.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate mechanisms that drive optic nerve sensitivity to elevated intraocular pressure, a major risk factor for optic nerve damage in glaucoma. The overarching goal is to determine how transient biomechanical strains on the optic nerve head prime astrocytes to develop greater glaucomatous dysfunction via the mechanosensitive channel Piezo1. The award will...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the role of myeloid cells in axon damage and degeneration associated with glaucoma. The research aims to determine whether NAD+-boosting interventions, which have shown promise in promoting axon protection, work through an anti-inflammatory mechanism by inhibiting myeloid cell recruitment. The award provides $423,767.00 over a 2-year period...
This $414,711 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) will support research at Albert Einstein College of Medicine to develop human organoid models for studying retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding. The goal is to elucidate the mechanisms underlying early optic disc and stalk development, RGC differentiation, and axon growth and pathfinding in human development and retinal diseases like glaucoma. The researchers...

This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $617,201 in funding to Emory University to conduct research aimed at improving the understanding and management of glaucoma, a leading cause of blindness. The key research objectives are to: 1) Map the 3D paths of optic nerve axons using optical coherence tomography (OCT) imaging; 2) Leverage AI to assess whether axonal deformations could serve as diagnostic and prognostic biomarkers for glaucoma; and 3) Use explainable AI to identify the specific types and locations of axonal deformations that contribute to vision loss patterns and progression across different glaucoma subtypes and demographics. This 5-year project, running from July 2025 to March 2030, seeks to provide novel insights into the biomechanical factors and injury mechanisms underlying glaucomatous optic neuropathy, with the goal of enabling more personalized approaches to diagnosing, monitoring, and treating this condition.

Generated 8/5/25, 5:04 AM