Project Grant R01EY036980
- The National Eye Institute awarded the University of Alabama at Birmingham $668,581 on April 1, 2026, under the Vision Research program (CFDA 93.867) to investigate bacterial-derived metabolites in diabetic retinopathy. Work is performed in Birmingham, Alabama, with a completion date of March 31, 2030. The recipient will conduct research on how gut microbiota-derived metabolites, particularly tryptophan metabolites, influence the development and progression of diabetic retinopathy. Prior work...
- The National Eye Institute awarded Pennsylvania State University's Penn State Milton S. Hershey Medical Center $430,650 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct exploratory and developmental research on the renal-retinal axis in diabetic retinopathy. The research addresses an unmet clinical need for preventative therapeutic strategies targeting the underlying molecular events that cause diabetic retinopathy in its early stages. Current standard-of-care...
- The National Eye Institute awarded The Leland Stanford Junior University $3,573,304 under the Vision Research program (CFDA 93.867) on September 15, 2025, to apply the TEMPO proteomic platform using human liquid biopsy samples to identify protein biomarker signatures and cells driving diabetic retinopathy stages and diabetic macular edema in living patients, and to determine the role of accelerated molecular aging in diabetic retinopathy using a proteomic clock. The TEMPO method integrates...
- The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP...
- The National Eye Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $383,750 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate oxidative stress and NLRP3 inflammasome activation in eye lens pathobiology during aging. The research examines molecular pathways linking reactive oxygen species amplification, dysregulation of antioxidant defenses, and inflammasome-driven inflammatory...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded the University of Rochester $684,914 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop human induced pluripotent stem cell (hiPSC)-derived retinal tissue models for disease research and cell-based therapeutic applications. The award funds two complementary aims. Aim 1 develops a microphysiological model of comprehensive hiPSC-derived retina that emulates the physiological spherical geometry of the human retina in vivo, suitable for...
- The National Eye Institute, a bureau of the Department of Health and Human Services National Institutes of Health, awarded $497,740 to the University of Illinois on April 1, 2026, under the Vision Research program (CFDA 93.867) to fund research into neuro-epithelial interactions in corneal disease and repair, with Principal Investigator Elmira Jalilian. The project investigates how corneal epithelial cells and trigeminal nerve fibers (the V1 ophthalmic branch) interact to maintain corneal...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $624,743 to the Regents of the University of California, doing business as University of California, Berkeley, on May 1, 2026, under the Vision Research program (CFDA 93.867). The award funds research into the function and regulation of constitutive prostaglandin D2 and DP receptor signaling in retinal health and neurodegeneration. The research investigates the physiological and...
- This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
The National Eye Institute, part of the National Institutes of Health, awarded the University of New Mexico Health Sciences Center $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate neutrophil extracellular traps and chemokine signaling in blood-retinal barrier disruption in diabetic retinopathy. The funded research targets mechanisms underlying diabetic retinopathy, the leading cause of vision loss in middle-aged adults. Current anti-VEGF therapies fail in approximately two-thirds of diabetic macular edema patients and require repeated eye injections with temporary benefits. The project hypothesizes that neutrophil extracellular traps and CXCL1/CXCR2 signaling pathways contribute to retinal hyper-vasopermeability in diabetes. Specific aims include characterizing the role of neutrophil extracellular traps and CXCL1/CXCR2 signaling in blood-retinal barrier alteration using streptozotocin-induced diabetes mouse models and genetically modified knockout animals; and identifying whether circulating markers of neutrophil extracellular traps associate with diabetic retinopathy severity to support potential therapeutic targeting. The award covers the period from September 1, 2026, through May 31, 2031, with work performed in Albuquerque, New Mexico.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 8/21/26 |