Project Grant R01EY037830
- The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $358,065 Project Grant to Revel Pharmaceuticals Inc., a biotechnology company in San Francisco, California. The grant is part of the NEI's Vision Research program (CFDA 93.867), which supports research to understand, prevent, and treat vision-related conditions and diseases. The goal of this Phase I grant is for Revel Pharmaceuticals to optimize lead drug candidates and demonstrate the activity of...
- This federal Project Grant award of $1,523,433.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Doheny Eye Institute in Pasadena, California to investigate the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy. The key products and services to be delivered include: Exploring how diabetes-induced stiffening of the retinal capillary basement membrane leads to activation of endothelial cells and inflammation,...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $144,362 to support research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The project aims to identify the spatial localization and functions of claudins, key tight junction proteins, in the retinal pigment epithelium (RPE) and test the hypothesis that regulation of RPE claudins by hyperglycemic...
- This $440,806 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) will fund research to define the role of the molecular chaperone protein P58IPK in retinal neurons during the pathogenesis of diabetic retinopathy. The research aims to investigate new molecular pathways by which P58IPK regulates protein and lipid homeostasis through the integrated stress response and lipid glycosylation processes, and evaluate the neuroprotective effects of targeting P58IPK and its...
- The National Eye Institute (NEI), part of the National Institutes of Health, awarded a $331,131 Project Grant under the Vision Research program (CFDA 93.867) to Physical Sciences Inc. (PSI) to develop and validate a high-resolution retinal imaging system with light flicker capabilities. This system aims to enable objective characterization of the photoreceptor response to light and quantify differences between normal and diseased eyes, particularly for patients with diabetic retinopathy. PSI,...
- The University of Southern California (USC) received a $480,140 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to develop new treatment strategies for diabetic retinopathy (DR). The key objectives are to: 1) evaluate the targeted delivery of therapeutic extracellular vesicles (exosomes) to areas of retinal vascular dysfunction in DR, and 2) determine if Müller glia-derived exosomes can protect the retinal neurovascular unit and mitigate DR...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, aims to advance understanding of the molecular and cellular mechanisms underlying diabetic retinopathy (DR) and diabetic macular edema (DME). The $1,786,652 award, granted on September 15, 2025, supports the application of the "TEMPO" proteomic platform to identify protein biomarker signatures and key cellular drivers of DR stages and DME using human liquid biopsy samples. The research will also leverage the proteomic clock to determine the role of accelerated molecular aging in DR progression. This work is funded under the NEI's Vision Research program (CFDA 93.867), which supports comprehensive research to prevent, treat, and understand vision-related conditions and diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 9/4/25 |