The National Eye Institute (NEI) awarded a $144,362 Project Grant (CFDA 93.867 - Vision Research) to the University of Chicago to conduct research on the neural mechanisms that support visual object categorization. The project aims to investigate how the brain's cortical hierarchies integrate multiple sensory features, such as motion direction and color, to enable flexible categorization of visual stimuli. Through large-scale electrophysiological recordings and paired inactivation-recording...
The National Eye Institute (NEI) awarded a $651,846 Project Grant under the Vision Research program (CFDA 93.867) to The Johns Hopkins University to identify the gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia. The 5-year project aims to determine if specific transcription factors are necessary and sufficient to regulate the progressive changes in retinal progenitor cell competence and neurogenesis over the course of development....
This $393,646 five-year Project Grant was awarded by the National Eye Institute (NEI), under the CFDA 93.867 Vision Research program, to the University of California, Los Angeles (UCLA) - Office of Research Administration. The funding will support research to comprehensively investigate the transcriptional control of neuronal positioning and connection formation in the retina, using starburst amacrine cells as a model. Specifically, the project aims to determine how the transcription factor...
The National Eye Institute (NEI) awarded a 5-year, $437,310 Project Grant (CFDA 93.867 Vision Research) to the University of Rochester to study the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate how upregulation and hyperactivation of the retinoic acid receptor (RAR) and downstream activation of the purinergic 2X isoform 7 receptor (P2X7) contributes to retinal ganglion cell hyperactivity and circuit corruption, which...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $224,300 to Northwestern University to develop a new preparation of the intact mouse eye and supporting vasculature. The goal is to use high-density electrodes to record spike responses from retinal ganglion cells (RGCs) following optic nerve injury. The project aims to validate the identification of RGCs using opto-tagging and measure the time course of dysfunction in RGCs after optic nerve cuts....
The National Eye Institute (NEI) awarded a $432,700 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Miami to investigate mechanisms by which the cytokine IL-27 regulates inflammation and promotes photoreceptor survival in retinal degeneration. The 4-year research project aims to define how IL-27 signaling controls detrimental and beneficial inflammatory responses, as well as identify the potential role of Müller glia-microglia interactions in...
This National Eye Institute (NEI) Project Grant award under the Vision Research program (CFDA 93.867) will fund research at the University of California, Los Angeles (UCLA) to investigate the visual function and transcriptomic profiles of excitatory neurons in the primary visual cortex (V1) of mice. The $228,718 grant, awarded on June 1, 2024, will support a 2-year project to establish correlations between the visual properties and genetic signatures of these V1 neurons, potentially revealing...
The National Eye Institute (NEI) awarded a $618,600 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The University of Iowa. The grant, effective from March 1, 2025 to February 28, 2030, supports research to develop image analysis algorithms for automated cell culture platforms. The objectives are to: 1) Train an AI algorithm to select induced pluripotent stem cell (iPSC) lines with a propensity for efficient retinal differentiation, and 2) Correlate...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), is funding research at St. Jude Children's Research Hospital Inc. on the role of Müller glia in acute and chronic inflammatory responses in the retina. The $606,034 award, spanning February 1, 2025 to January 31, 2030, will support the researchers' efforts to develop a comprehensive understanding of how different retinal cell types, particularly Müller glia,...
This federal Project Grant award of $131,281 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research by Northwestern University to investigate the role of myeloid cell transmigration in the progression of non-proliferative diabetic retinopathy (DR). The research aims to determine whether and when blocking the migration of CCR2-responsive myeloid cells can halt inflammation and disease progression in the mouse retina, as well as assess if...