This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $638,625 to the University of California, San Diego (UCSD) to develop a "Bruch's Membrane-on-a-Chip" technology for studying the formation of drusen deposits, a key factor in the progression of age-related macular degeneration (AMD). The research aims to investigate the determinants of lipoprotein retention in Bruch's membrane, including the role of apolipoprotein composition and heparan...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The research aims to optimize an in vitro outer blood-retina barrier model, generate isogenic models with different APOE...
This Project Grant award of $620,149 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a multi-center research program to develop advanced genome editing technologies for modifying critical genetic risk factors associated with age-related macular degeneration (AMD). The research team, led by the University of Iowa, will conduct base editing and prime editing of AMD risk loci in human cells, including induced pluripotent stem...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will provide $1,173,062 to The University of Iowa to investigate the role of extracellular matrix stiffness and genetic risk factors in age-related macular degeneration (AMD)-associated epithelial-to-mesenchymal transition. The research aims to determine how changes in matrix biomechanics impact the fate of retinal pigmented epithelial and choroidal endothelial cells using in vitro and ex vivo models of...
This Project Grant award from the National Eye Institute (NEI) of the National Institutes of Health (CFDA 93.867 - Vision Research) provides $658,889 to the University of Rochester to investigate the role of the pro-inflammatory enzyme PLA2G2A/sPLA2-IIA in age-related macular degeneration (AMD). The research aims to utilize human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models to critically evaluate the mutation-independent pathogenic role of PLA2G2A in...
This federal Project Grant award, provided by the National Eye Institute (CFDA 93.867 Vision Research), supports research at the Whitehead Institute for Biomedical Research to systematically identify and characterize novel oxidative protective genes that can prevent retinal pigment epithelium (RPE) degeneration and age-related macular degeneration (AMD). The $173,016 award, effective from Aug 1, 2025 to Jul 31, 2027, will fund a project focused on three primary aims: 1) elucidating the...
The National Eye Institute (NEI) awarded a $291,375 Project Grant (CFDA 93.867 - Vision Research) to the University of Connecticut Health Center to develop a novel mouse model for studying age-related choroidal neovascularization (ARCNV), a key hallmark of wet age-related macular degeneration (AMD). The award, spanning from August 1, 2024 to July 31, 2026, aims to systematically characterize the ARCNV model, which mimics the genetic, environmental, and age-related factors associated with wet...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides USD 521,572.00 to East Tennessee State University to investigate the role of histone expression in retinal pigment epithelium (RPE) aging and its relationship to age-related macular degeneration (AMD). The research aims to define signatures of histone expression in the aging RPE and determine the cellular effects of histone depletion on RPE homeostasis and AMD progression....
This $1,330,026 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) will support the development of two new mouse models of geographic atrophy, the advanced form of dry age-related macular degeneration (AMD). The goal is to use these models to evaluate the potential of a novel antioxidant, deuterated docosahexaenoic acid (D-DHA), to protect the retinal pigment epithelium and prevent or treat AMD progression. The research will be conducted by the University of...
This $433,841 federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports the development of computational methods and deep learning models to analyze imaging data and identify biomarkers for age-related macular degeneration (AMD). The goal is to improve understanding of AMD disease progression and response to treatment. Specifically, the project will develop deep neural network models to analyze optical coherence tomography,...