Project Grant R01EY036481

Award Date 9/30/24
Completion Date 7/31/28
Dollars Obligated $1.4M
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
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  1. Correlate the delayed corneal wound regeneration with the extent of corneal nerve degradation in mouse models, and quantify the associated ocular pain behaviors.

  2. Delineate the activating mechanism of corneal sensory fibers by ammonia, and elucidate the changes in corneal sensory fibers over time after ammonia exposure.

  3. Investigate the effects of activity-dependent neuronal silencing in preventing over-activation of corneal sensory nerves by ammonia, to alleviate ocular pain and promote corneal wound healing.

The research aims to reveal a previously unrecognized neural mechanism behind corneal injuries by ammonia, and develop novel therapeutic strategies to address this critical public health issue. The project will be conducted at The Washington University in St. Louis, Missouri over the period of September 30, 2024 to July 31, 2028.

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