This federal Project Grant award of $715,098 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to enhance glaucoma risk prediction through advanced genomics and machine learning. The key products and services to be delivered include: Improving polygenic risk score (PRS) performance for glaucoma by leveraging natural language processing techniques and electronic health record data from over 68,000 patients to extract refined glaucoma phenotypes. The...
The National Eye Institute (NEI) has awarded a $466,125 Federal Project Grant (CFDA 93.867 - Vision Research) to Weill Medical College of Cornell University to develop and validate a new artificial intelligence approach to improve the fairness of predictive models for primary open-angle glaucoma (POAG) risk estimation. The project aims to study algorithmic bias in POAG risk prediction and examine the impact of transferring bias from a biased model to a demographically balanced dataset. The...
The National Eye Institute (NEI), through its Vision Research federal grant program (CFDA 93.867), awarded a $679,159 Project Grant to The Schepens Eye Research Institute, Inc. in Boston, Massachusetts. The grant, awarded on May 1, 2025, supports research aimed at understanding how aging and elevated intraocular pressure (IOP) contribute to the development of glaucoma and impact retinal ganglion cells (RGCs). The research project will investigate the transcriptomic changes in RGCs due to aging...
This $185,000 Project Grant award from the National Eye Institute (NEI) under CFDA 93.867 (Vision Research) supports research to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The primary awardee, the University of North Texas Health Science Center at Fort Worth, will employ computational pharmacology approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP protein-protein interaction, a key pathogenic mechanism contributing...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to define the role of the RIG-I protein in the pathogenesis of glaucoma and the response to viral infections. The $603,251 award, effective from July 1, 2025 to April 30, 2030, will support the following key activities: Elucidating the molecular mechanisms by which RIG-I variants cause glaucoma in a mouse model through genetic perturbation, histological, and single-cell...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting the development of equitable deep learning models for automated glaucoma screening. The $754,779 award, with a performance period from Sep 30, 2024 to Jul 31, 2029, aims to assess the performance equity of existing deep learning models, develop identity-conditioned generative models to improve data equality, and create fair identity normalization techniques to equalize...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $617,201 in funding to Emory University to conduct research aimed at improving the understanding and management of glaucoma, a leading cause of blindness. The key research objectives are to: 1) Map the 3D paths of optic nerve axons using optical coherence tomography (OCT) imaging; 2) Leverage AI to assess whether axonal deformations could serve as diagnostic and prognostic biomarkers for...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis in glaucoma through senolytic treatments. The $234,000 award to Oregon Health & Science University aims to use senolytics and senoreverters to restore TM cell IOP homeostatic function in glaucomatous tissue, with or without stem cell transplantation. This research has the...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The research aims to optimize an in vitro outer blood-retina barrier model, generate isogenic models with different APOE...
This Project Grant award, valued at $728,165 and provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research into the role of orexins in regulating intraocular pressure (IOP) as it relates to glaucoma. The key objectives are to: Examine the role of the brainstem raphe pallidus region in mediating DMH/PEF-induced IOP elevations by measuring the impact of local orexin receptor antagonists. Assess the degree to which orexin...