Project Grant R01ES038742
- The National Institute of Environmental Health Sciences awarded Brown University $582,295 on August 21, 2026, under the Environmental Health program (CFDA 93.113) to investigate mechanisms of phthalate toxicity in testicular development and long-term reproductive function. The project, titled "Mechanisms of Phthalate Toxicity in Testis Development and Later-Life Function," will define how phthalate exposure during fetal development disrupts testicular germ cell development and...
- The National Institute of Environmental Health Sciences awarded the University of North Carolina at Chapel Hill $495,067 on September 12, 2025, under the Environmental Health program (CFDA 93.113) to investigate associations between prenatal phthalate and phthalate alternative exposures and fetal and pediatric cardiometabolic outcomes. The research uses the HPP-3D study cohort, which documented phthalate exposure in 90% of pregnancies. The award funds two phases of work. During the K99 phase,...
- The National Institute of Environmental Health Sciences awarded Clemson University $167,562 under the Environmental Health program (CFDA 93.113) on August 20, 2026, to investigate the effects of preconception phthalate exposure on implantation and placentation. The project addresses a knowledge gap in reproductive toxicology by examining how endocrine-disrupting chemical exposure during the preconception window—between puberty and pregnancy—affects maternal reproductive tissue adaptations that...
- The National Institute of Environmental Health Sciences awarded the University of Southern California $1.256 million on April 10, 2026, under the Environmental Health program (CFDA 93.113) to conduct translational research on per- and polyfluoroalkyl substances (PFAS) and metabolic diseases. The award funds four interconnected research areas. Area 1 analyzes epidemiological data from over 50,000 participants across 18 diverse cohorts to examine PFAS associations with omics biomarkers and...
- The National Institute of Environmental Health Sciences awarded the University of Massachusetts $752,690 on August 13, 2026, for research on preconception and early pregnancy exposure to endocrine-disrupting chemicals under the Environmental Health grant program (CFDA 93.113). The project investigates how exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs), and trace elements affects women's reproductive health and the ability to achieve...
- The National Institute of Environmental Health Sciences awarded Drexel University $111,199 on April 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate the role of phthalates, phenols, and their sources on phenotypic variability in autism and co-occurring neurodevelopmental disorders, obesity, and asthma. The recipient will use data from the Environmental Influences on Child Health Outcomes (ECHO) program, an NIH-funded consortium of longitudinal U.S.-based cohort...
- The National Institute of Environmental Health Sciences awarded Emory University $3.9 million on August 21, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life environmental exposures influence adult gonadal health and reproductive function. The research uses the Growing Up Today Study, a prospective cohort of 27,706 children enrolled beginning in 1996 and 2004 whose mothers participate in the Nurses' Health Study II. The study will examine cumulative...
- Federal Grant Award Summary Midwestern University received a $521,992 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective September 1, 2025, through August 31, 2028. The grant supports research and career development activities investigating how phthalate exposure disrupts reproductive function through Liver Receptor Homolog-1 (LRH1) signaling pathways in Sertoli cells. The primary deliverables include...
- Federal Project Grant Award Summary Texas A&M University System Health Science Center received a $2.47 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 15, 2025, with completion anticipated by September 14, 2029. The award supports mechanistic research investigating phthalate-induced epigenetic regulations in adipose tissues and their role in metabolic dysfunction. The project...
- The National Institute of Environmental Health Sciences awarded the University of New England $163,856 on April 10, 2026, under the Environmental Health program (CFDA 93.113) to conduct a prospective study of per- and polyfluoroalkyl substance (PFAS) mixtures and pregnancy outcomes using data from the Study of Environment, Lifestyle, and Fibroids (SELF). The research leverages an existing cohort of reproductive-aged Black women from Detroit, Michigan, recruited between 2010 and 2012 when...
The National Institute of Environmental Health Sciences awarded the University of Southern California $4.061 million on August 25, 2026, under the Environmental Health program (CFDA 93.113, Assistance Listing R01ES038742) to investigate phthalate exposure, dietary effect modification, and human reproductive health. The research addresses whether serum levels of n-3 polyunsaturated fatty acids and carotenoids modify the adverse reproductive effects of phthalate exposure. The project will evaluate associations between urinary phthalate metabolite concentrations—individually and as a mixture—and their effect modification by serum n-3 polyunsaturated fatty acids and carotenoids on three outcomes: markers of ovarian reserve, semen parameters, and pregnancy and perinatal endpoints. The work will leverage data and biological samples from the Environment and Reproductive Health (EARTH) study, a prospective preconception cohort of couples recruited from a fertility clinic and followed through delivery, in which urine, serum, and semen samples have been collected along with clinical data on pregnancy and perinatal outcomes. Place of performance is Los Angeles, California. The period of performance runs through August 24, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.1m | 8/19/26 |